L
Lilian I. Plotkin
Researcher at Indiana University
Publications - 141
Citations - 12733
Lilian I. Plotkin is an academic researcher from Indiana University. The author has contributed to research in topics: Osteocyte & Osteoblast. The author has an hindex of 49, co-authored 127 publications receiving 11433 citations. Previous affiliations of Lilian I. Plotkin include Veterans Health Administration & University of Arkansas for Medical Sciences.
Papers
More filters
Journal ArticleDOI
Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity.
Stavroula Kousteni,Teresita Bellido,Lilian I. Plotkin,Charles A. O'Brien,Donald L. Bodenner,Li Han,K. Han,G. B. DiGregorio,John A. Katzenellenbogen,Benita S. Katzenellenbogen,Paula K. Roberson,Robert S. Weinstein,Robert L. Jilka,Stavros C. Manolagas +13 more
TL;DR: A novel paradigm of sex steroid action on osteoblasts, osteocytes, embryonic fibroblasts, and HeLa cells involving activation of a Src/Shc/ERK signaling pathway and attenuating apoptosis is demonstrated, providing proof of principle for the development of function-specific-as opposed to tissue-selective-and gender-neutral pharmacotherapeutics.
Journal ArticleDOI
Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin
Lilian I. Plotkin,Robert S. Weinstein,Robert S. Weinstein,A. Michael Parfitt,Paula K. Roberson,Stavros C. Manolagas,Stavros C. Manolagas,Teresita Bellido +7 more
TL;DR: Alendronate abolished the increased prevalence of apoptosis in vertebral cancellous bone osteocytes and osteoblasts that follows prednisolone administration to mice, suggesting that the therapeutic efficacy of BPs or calcitonin in diseases such as glucocorticoid-induced osteoporosis may be due to their ability to prevent osteocyte and osteoblast apoptosis.
Journal ArticleDOI
Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength.
Charles A. O'Brien,Dan Jia,Lilian I. Plotkin,Teresita Bellido,Cara C. Powers,Scott A. Stewart,Stavros C. Manolagas,Robert S. Weinstein +7 more
TL;DR: The results suggest that glucocorticoid-induced loss of bone strength results in part from increased death of osteocytes, independent of bone loss, and demonstrate for the first time that excess glucOCorticoids directly affect bone forming cells in vivo.
Journal ArticleDOI
Skeletal Involution by Age-associated Oxidative Stress and Its Acceleration by Loss of Sex Steroids
Maria Almeida,Li Han,Marta Martin-Millan,Lilian I. Plotkin,Scott A. Stewart,Paula K. Roberson,Stavroula Kousteni,Charles A. O'Brien,Teresita Bellido,A. Michael Parfitt,Robert S. Weinstein,Robert L. Jilka,Stavros C. Manolagas +12 more
TL;DR: It is concluded that the oxidative stress that underlies physiologic organismal aging in mice may be a pivotal pathogenetic mechanism of the age-related bone loss and strength.
Journal ArticleDOI
Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis.
Teresita Bellido,A. Afshan Ali,Igor Gubrij,Lilian I. Plotkin,Qiang Fu,Charles A. O'Brien,Stavros C. Manolagas,Robert L. Jilka +7 more
TL;DR: In this article, the effects of PTH on Sost, a Runx2 target gene expressed in osteocytes, were studied, which antagonizes the pro-osteoblastogenic actions of bone morphogenetic proteins and Wnts.