L
Lily E. Leiva
Researcher at University Medical Center New Orleans
Publications - 18
Citations - 3117
Lily E. Leiva is an academic researcher from University Medical Center New Orleans. The author has contributed to research in topics: Antigen & Antibody. The author has an hindex of 14, co-authored 18 publications receiving 2913 citations.
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Journal ArticleDOI
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
Salima Hacein-Bey-Abina,Alexandrine Garrigue,Gary P. Wang,Jean Soulier,Annick Lim,Estelle Morillon,Emmanuelle Clappier,Laure Caccavelli,Eric Delabesse,Kheira Beldjord,Vahid Asnafi,Elizabeth Macintyre,Liliane Dal Cortivo,Isabelle Radford,Nicole Brousse,François Sigaux,Despina Moshous,Julia Hauer,Arndt Borkhardt,Bernd H. Belohradsky,Uwe Wintergerst,Maria C. Velez,Lily E. Leiva,Ricardo U. Sorensen,NM Wulffraat,Stéphane Blanche,Frederic D. Bushman,Alain Fischer,Marina Cavazzana-Calvo +28 more
TL;DR: These findings functionally specify a genetic network that controls growth in T cell progenitors and led to sustained remission in 3 of the 4 cases of T cell leukemia, but failed in the fourth.
Journal ArticleDOI
Efficacy of Gene Therapy for X-Linked Severe Combined Immunodeficiency
Salima Hacein-Bey-Abina,Julia Hauer,Annick Lim,Capucine Picard,Gary P. Wang,Charles C. Berry,Chantal Martinache,Frédéric Rieux-Laucat,Sylvain Latour,Bernd H. Belohradsky,Lily E. Leiva,Ricardo U. Sorensen,Marianne Debré,Jean-Laurent Casanova,Stéphane Blanche,Anne Durandy,Frederic D. Bushman,Alain Fischer,Marina Cavazzana-Calvo +18 more
TL;DR: After nearly 10 years of follow-up, gene therapy was shown to have corrected the immunodeficiency associated with SCID-X1 and may be an option for patients who do not have an HLA-identical donor for hematopoietic stem-cell transplantation and for whom the risks are deemed acceptable.
Journal ArticleDOI
Influence of age on the response to Streptococcus pneumoniae vaccine in patients with recurrent infections and normal immunoglobulin concentrations.
Ricardo U. Sorensen,Lily E. Leiva,Felipe C. Javier,Daniela M. Sacerdote,Nicola Bradford,Boyd Butler,Patricia A. Giangrosso,Cleveland Moore +7 more
TL;DR: The definition of what constitutes an adequate response to pneumococcal immunization needs further definition, and it is clear that age has an important influence on the intensity of the response to most pneumococal polysaccharides.
Journal ArticleDOI
Response to a heptavalent conjugate Streptococcus pneumoniae vaccine in children with recurrent infections who are unresponsive to the polysaccharide vaccine.
Ricardo U. Sorensen,Lily E. Leiva,Patricia A. Giangrosso,Boyd Butler,Felipe C. Javier,Daniela M. Sacerdote,Nicola Bradford,Cleveland Moore +7 more
TL;DR: The results show that a pneumococcal conjugate vaccine is capable of inducing an IgG response in patients with recurrent infections who had failed to mount an adequate response to the polysaccharide vaccine.
Journal Article
Erratum: Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy (New England Journal of Medicine (April 18, 2002) 346 (1185-1193))
Salima Hacein-Bey-Abina,F Le Deist,Frédérique Carlier,Cécile Bouneaud,Christophe Hue,J P de Villartay,Adrian J. Thrasher,NM Wulffraat,Ricardo U. Sorensen,Sophie Dupuis-Girod,A Fischer,E. Graham Davies,W Kuis,Lily E. Leiva,Marina Cavazzana-Calvo +14 more