U
Uwe Wintergerst
Researcher at Ludwig Maximilian University of Munich
Publications - 67
Citations - 7569
Uwe Wintergerst is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Chronic granulomatous disease & Viral load. The author has an hindex of 20, co-authored 62 publications receiving 7089 citations. Previous affiliations of Uwe Wintergerst include German Cancer Research Center & Boston Children's Hospital.
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Journal ArticleDOI
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.
Salima Hacein-Bey-Abina,C von Kalle,C von Kalle,Manfred Schmidt,Matthew P. McCormack,NM Wulffraat,Philippe Leboulch,Annick Lim,Cameron S. Osborne,R. Pawliuk,Estelle Morillon,R. Sorensen,A. Forster,Peter Fraser,Jeffrey I. Cohen,G de Saint Basile,Ian E. Alexander,Uwe Wintergerst,Thierry Frebourg,Alain Aurias,Dominique Stoppa-Lyonnet,Serge Romana,I. Radford-Weiss,Fabian Gross,Françoise Valensi,Eric Delabesse,Elizabeth Macintyre,F. Sigaux,Jean Soulier,L. E. Leiva,Manuela Wissler,Claudia Prinz,Terence H. Rabbitts,F. Le Deist,Alain Fischer,Marina Cavazzana-Calvo +35 more
TL;DR: Retrovirus vector insertion can trigger deregulated premalignant cell proliferation with unexpected frequency, most likely driven by retrovirus enhancer activity on the LMO2 gene promoter.
Journal ArticleDOI
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
Salima Hacein-Bey-Abina,Alexandrine Garrigue,Gary P. Wang,Jean Soulier,Annick Lim,Estelle Morillon,Emmanuelle Clappier,Laure Caccavelli,Eric Delabesse,Kheira Beldjord,Vahid Asnafi,Elizabeth Macintyre,Liliane Dal Cortivo,Isabelle Radford,Nicole Brousse,François Sigaux,Despina Moshous,Julia Hauer,Arndt Borkhardt,Bernd H. Belohradsky,Uwe Wintergerst,Maria C. Velez,Lily E. Leiva,Ricardo U. Sorensen,NM Wulffraat,Stéphane Blanche,Frederic D. Bushman,Alain Fischer,Marina Cavazzana-Calvo +28 more
TL;DR: These findings functionally specify a genetic network that controls growth in T cell progenitors and led to sustained remission in 3 of the 4 cases of T cell leukemia, but failed in the fourth.
Journal ArticleDOI
Gene Therapy for Immunodeficiency Due to Adenosine Deaminase Deficiency
Alessandro Aiuti,Federica Cattaneo,Stefania Galimberti,Ulrike Benninghoff,Barbara Cassani,Luciano Callegaro,Samantha Scaramuzza,Grazia Andolfi,Massimiliano Mirolo,Immacolata Brigida,Antonella Tabucchi,Filippo Carlucci,Martha M. Eibl,Memet Aker,Shimon Slavin,Hamoud Al-Mousa,Abdulaziz Al Ghonaium,Alina Ferster,Andrea Duppenthaler,Luigi D. Notarangelo,Uwe Wintergerst,Rebecca H. Buckley,Marco Bregni,Sarah Marktel,Maria Grazia Valsecchi,Pier Luca Rossi,Fabio Ciceri,Roberto Miniero,Claudio Bordignon,Claudio Bordignon,Maria Grazia Roncarolo +30 more
TL;DR: Gene therapy, combined with reduced-intensity conditioning, is a safe and effective treatment for SCID in patients with ADA deficiency and effective protection against infections and improvement in physical development made a normal lifestyle possible.
Journal ArticleDOI
Long-term follow-up and outcome of 39 patients with chronic granulomatous disease.
Johannes G. Liese,Sibylle Kloos,Verena Jendrossek,Theoni Petropoulou,Uwe Wintergerst,Gundula Notheis,M. Gahr,Bernd H. Belohradsky +7 more
TL;DR: Infections with Aspergillus species have become the major cause of infectious complications and death in patients withCGD and prophylactic and therapeutic measures are needed to further increase life expectancy and quality for patients with CGD.
Journal ArticleDOI
X-linked thrombocytopenia (XLT) due to WAS mutations: Clinical characteristics, long-term outcome, and treatment options
Michael H. Albert,Tanja C. Bittner,Shigeaki Nonoyama,Lucia Dora Notarangelo,Siobhan O. Burns,Kohsuke Imai,Teresa Espanol,Anders Fasth,Isabelle Pellier,Gabriele Strauss,Tomohiro Morio,Benjamin Gathmann,Jeroen G. Noordzij,Cristina Fillat,Manfred Hoenig,Michaela Nathrath,Alfons Meindl,Philipp Pagel,Uwe Wintergerst,Alain Fischer,Adrian J. Thrasher,Bernd H. Belohradsky,Hans D. Ochs +22 more
TL;DR: An analysis of the clinical outcome and molecular basis of patients with XLT shows excellent long-term survival but also a high probability of severe disease-related complications, which will allow better decision making when considering treatment options for individual patients withXLT.