Limin Pan

TL;DR: TAT peptide has been employed to conjugate onto mesoporous silica nanoparticles (MSNs-TAT) with high payload for nuclear-targeted drug delivery for the first time, and may provide an effective strategy for the design and development of cell-nuclear-targeting drug delivery.

TL;DR: It is highly desirable to develop NIR remote-controllable MSNs-based system which can be used both in vitro and in vivo, which, however, has not been well addressed and remains a great challenge.

TL;DR: With the nuclear drug delivery fashion, DOX-MSNs-TAT presents a promising strategy in overcoming MDR in cancer cells and improving the therapeutic index of currently available chemotherapeutics by enhancing therapeutic efficacy and reducing side effects.

TL;DR: Mesoporous silica nanoparticles functionalized with peptides are developed for sequential drug delivery and a tumor in a murine xenograft model is successfully regressed.

TL;DR: Colloidal hollow periodic mesoporous organosilica nanoparticles with tunable compositions and highly hybridized nanostructures are successfully synthesized by a simple, easily scale-up but versatile silica-etching chemistry (alkaline or HF etching) for their applications in nano-fabrication and nano-medicine.