L
Lin Chen
Researcher at Chinese PLA General Hospital
Publications - 164
Citations - 4585
Lin Chen is an academic researcher from Chinese PLA General Hospital. The author has contributed to research in topics: Cancer & Stem cell. The author has an hindex of 35, co-authored 154 publications receiving 3593 citations. Previous affiliations of Lin Chen include Wenzhou Medical College.
Papers
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Journal ArticleDOI
Maternal and Neonatal Outcomes of Pregnant Women With Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case-Control Study.
Na Li,Lefei Han,Min Peng,Yuxia Lv,Yin Ouyang,Kui Liu,Linli Yue,Qiannan Li,Guoqiang Sun,Lin Chen,Lin Yang +10 more
TL;DR: Severe maternal and neonatal complications were not observed in pregnant women with COVID-19 pneumonia who had vaginal delivery or caesarean section and the need of effective screening on admission is highlighted.
Journal ArticleDOI
A proteomic landscape of diffuse-type gastric cancer
Sai Ge,Xia Xia,Chen Ding,Chen Ding,Bei Zhen,Quan Zhou,Jinwen Feng,Jinwen Feng,Jiajia Yuan,Rui Chen,Yumei Li,Zhongqi Ge,Jiafu Ji,Lianhai Zhang,Jiayuan Wang,Zhongwu Li,Yumei Lai,Ying Hu,Yanyan Li,Yilin Li,Jing Gao,Lin Chen,Jianming Xu,Chunchao Zhang,Sung Yun Jung,Jong Min Choi,Antrix Jain,Mingwei Liu,Lei Song,Wanlin Liu,Gaigai Guo,Tongqing Gong,Yin Huang,Yang Qiu,Wenwen Huang,Tieliu Shi,Weimin Zhu,Yi Wang,Yi Wang,Fuchu He,Fuchu He,Lin Shen,Jun Qin,Jun Qin,Jun Qin +44 more
TL;DR: A mutation and proteome dataset for 84 DGC patients is presented, identifying three major classes of DGC and indicating potential targets for therapy and the benefit of proteomic analysis in cancer molecular subtyping.
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Sonic Hedgehog Pathway Is Essential for Maintenance of Cancer Stem-Like Cells in Human Gastric Cancer
Zhou Song,Wen Yue,Bo Wei,Ning Wang,Tao Li,Lidong Guan,Shuangshuang Shi,Quan Zeng,Xuetao Pei,Lin Chen +9 more
TL;DR: The data suggested that SHH pathway was essential for maintenance of CSLCs in human gastric cancer.
Journal ArticleDOI
Hepatocellular carcinoma‐associated mesenchymal stem cells promote hepatocarcinoma progression: Role of the S100A4‐miR155‐SOCS1‐MMP9 axis
Xinlong Yan,Yali Jia,Lin Chen,Quan Zeng,Junnian Zhou,Chun-Jiang Fu,Haixu Chen,Hong-Feng Yuan,Zhi-Wei Li,Lei Shi,Ying-Chen Xu,Jing-Xue Wang,Xiaomei Zhang,Lijuan He,Chao Zhai,Wen Yue,Xuetao Pei +16 more
TL;DR: S100A4 secreted from LC‐MSCs promotes the expression of miR‐155, which mediates the down‐regulation of suppressor of cytokine signaling 1, leading to the subsequent activation of STAT3 signaling, which results in increased tumor invasiveness.
Journal ArticleDOI
Genome-Wide lncRNA Microarray Profiling Identifies Novel Circulating lncRNAs for Detection of Gastric Cancer.
Kecheng Zhang,Hong-Zhi Shi,Hongqing Xi,Xiaosong Wu,Jianxin Cui,Yunhe Gao,Wenquan Liang,Chong Hu,Yi Liu,Jiyang Li,Ning Wang,Bo Wei,Lin Chen +12 more
TL;DR: It is demonstrated that this panel of five plasma lncRNAs could serve as a set of novel diagnostic biomarkers for GC detection, and high values of the lncRNA-based index were correlated with tumor size, which indicates its ability to monitor tumor dynamics.