S
Sung Yun Jung
Researcher at Baylor College of Medicine
Publications - 177
Citations - 11533
Sung Yun Jung is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 40, co-authored 147 publications receiving 9647 citations. Previous affiliations of Sung Yun Jung include Seoul National University & Chonnam National University.
Papers
More filters
Journal ArticleDOI
MeCP2, a key contributor to neurological disease, activates and represses transcription.
Maria H. Chahrour,Sung Yun Jung,Chad A. Shaw,Xiaobo Zhou,Stephen T. C. Wong,Jun Qin,Huda Y. Zoghbi +6 more
TL;DR: It is shown that MeCP2 associates with the transcriptional activator CREB1 at the promoter of an activated target but not a repressed target, and that it can function as both an activator and a repressor of transcription.
Journal ArticleDOI
SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity
Estela Jacinto,Valeria Facchinetti,Dou Liu,Nelyn Soto,Shiniu Wei,Sung Yun Jung,Qiaojia Huang,Jun Qin,Bing Su +8 more
TL;DR: It is reported that SIN1/MIP1 is an essential TORC2/PDK2 subunit for Akt/PKB Ser473 phosphorylation in the hydrophobic motif and that the Sin1-rictor-mTOR function in Akt-Ser473 phosphories is required forTORC2 function in cell survival but is dispensable for TORC1 function.
Journal ArticleDOI
Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells
Jiancong Liang,Ma Wan,Yi Zhang,Peili Gu,Peili Gu,Huawei Xin,Sung Yun Jung,Jun Qin,Jiemin Wong,Jiemin Wong,Austin J. Cooney,Dan Liu,Zhou Songyang +12 more
TL;DR: Characterization of endogenous Nanog and Oct4 protein complexes in mouse ES cells found that these transcription factors interact with each other and associate with proteins from multiple repression complexes, including the NuRD, Sin3A and Pml complexes.
Journal ArticleDOI
Negative regulation of the deacetylase SIRT1 by DBC1
TL;DR: It is shown that DBC1 (deleted in breast cancer 1) acts as a native inhibitor of SIRT1 in human cells and promotes p53-mediated apoptosis through specific inhibition of Sirt1.
Journal ArticleDOI
Analysis of the Human Endogenous Coregulator Complexome
Anna Malovannaya,Rainer B. Lanz,Sung Yun Jung,Yaroslava Bulynko,Nguyen T. Le,Doug W. Chan,Chen Ding,Yi Shi,Nur Yucer,Giedre Krenciute,Beom-Jun Kim,Chunshu Li,Rui Chen,Wei Li,Yi Wang,Bert W. O'Malley,Jun Qin +16 more
TL;DR: A tiered interplay within networks that share common proteins is revealed, providing a conceptual organization of a cellular proteome composed of minimal endogenous modules (MEMOs), complex isoforms (uniCOREs), and regulatory complex-complex interaction networks (CCIs).