L
Lin Chen
Researcher at City University of Hong Kong
Publications - 5
Citations - 70
Lin Chen is an academic researcher from City University of Hong Kong. The author has contributed to research in topics: Polyketide synthase & Polyketide. The author has an hindex of 2, co-authored 3 publications receiving 10 citations.
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Journal ArticleDOI
Molecular Basis for the Biosynthesis of an Unusual Chain-Fused Polyketide, Gregatin A
Wei-Guang Wang,Hang Wang,Lian-Qiong Du,Min Li,Lin Chen,Jian Yu,Gui-Guang Cheng,Meng-Tao Zhan,Qiu-Fen Hu,Lihan Zhang,Min Yao,Yudai Matsuda +11 more
TL;DR: The biosynthetic route leading to 1 is established, and it is illuminated that 1 is generated by the fusion of two different polyketide chains, which are synthesized by a single PKS GrgA with the aid of a trans-acting enoylreductase GrgB.
Journal ArticleDOI
Heterologous Biosynthesis of Tetrahydroxanthone Dimers: Determination of Key Factors for Selective or Divergent Synthesis.
TL;DR: In this paper, the Baeyer-Villiger monooxygenase, AacuH, was used to synthesize tetrahydroxanthone dimers in Aspergillus oryzae.
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Aspcandine: A Pyrrolobenzazepine Alkaloid Synthesized by a Fungal Nonribosomal Peptide Synthetase-Polyketide Synthase Hybrid.
TL;DR: Characterization of an orphan biosynthetic gene cluster found in the fungus Aspergillus candidus CBS 102.13 resulted in the discovery of a pyrrolobenzazepine alkaloid, aspcandine, which is synthesized by the nonribosomal peptide synthetase-polyketide synthase hybrid AcdB, which unusually incorporates 3-hydroxy-l-kynurenine as a building block.
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Discovery of Pyranoviolin A and Its Biosynthetic Gene Cluster in Aspergillus violaceofuscus.
TL;DR: It is indicated that metabolite analysis of genome-sequenced microorganisms whose metabolites have been largely unexplored facilitates the discovery of new secondary metabolites along with their biosynthetic gene clusters.
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Depside Bond Formation by the Starter-Unit Acyltransferase Domain of a Fungal Polyketide Synthase.
TL;DR: A polyketide synthase from the fungus Aspergillus duricaulis is discovered and it is determined that depside bond formation is catalyzed by the starter-unit acyltransferase (SAT) domain of DrcA, a previously undescribed form of SAT domain chemistry.