Y
Yoshihiro Ishikawa
Researcher at Yokohama City University
Publications - 259
Citations - 7742
Yoshihiro Ishikawa is an academic researcher from Yokohama City University. The author has contributed to research in topics: Adenylyl cyclase & Receptor. The author has an hindex of 46, co-authored 253 publications receiving 6921 citations. Previous affiliations of Yoshihiro Ishikawa include Rutgers University & Cardiovascular Institute Hospital.
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Journal ArticleDOI
Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress
Lin Yan,Dorothy E. Vatner,J. Patrick O'Connor,Andreas S. Ivessa,Hui Ge,Wei Chen,Shinichi Hirotani,Yoshihiro Ishikawa,Junichi Sadoshima,Stephen F. Vatner +9 more
TL;DR: A significant activation of the Raf/MEK/ERK signaling pathway and upregulation of cell protective molecules, including superoxide dismutase are demonstrated and suggest that AC is a fundamentally important mechanism regulating lifespan and stress resistance.
Journal ArticleDOI
Adverse Effects of Chronic Endogenous Sympathetic Drive Induced by Cardiac Gsα Overexpression
Mitsunori Iwase,Sanford P. Bishop,Masami Uechi,Dorothy E. Vatner,Richard P. Shannon,Raymond K. Kudej,David C. Wight,Thomas Wagner,Yoshihiro Ishikawa,Charles J. Homcy,Stephen F. Vatner +10 more
TL;DR: The results suggest that Gsalpha overexpression enhances the efficacy of the beta-adrenergic receptor-Gs-adenylyl cyclase signaling pathway, which leads to augmented inotropic and chronotropic responses to endogenous sympathetic stimulation.
Journal ArticleDOI
The Prostanoid EP4 Receptor and Its Signaling Pathway
TL;DR: The aim of this review is to present current findings on the biologic functions of the EP4 receptor and discuss its diversity from the standpoint of EP4-mediated signaling.
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Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload
Satoshi Okumura,Gen Takagi,Jun-ichi Kawabe,Guiping Yang,Ming-Chih Lee,Chull Hong,Jing Liu,Dorothy E. Vatner,Junichi Sadoshima,Stephen F. Vatner,Yoshihiro Ishikawa +10 more
TL;DR: It is suggested that limiting type 5 AC plays a protective role in response to pressure overload and the development of heart failure, potentially through limiting the incidence of myocardial apoptosis.
Journal ArticleDOI
A role for Piezo2 in EPAC1-dependent mechanical allodynia
Niels Eijkelkamp,John E. Linley,J. M. Torres,J. M. Torres,Lucy A. Bee,Anthony H. Dickenson,M. Gringhuis,Michael S. Minett,G. S. Hong,G. S. Hong,E. Lee,E. Lee,Uhtaek Oh,Yoshihiro Ishikawa,F. J. Zwartkuis,James J. Cox,John N. Wood,John N. Wood +17 more
TL;DR: It is shown that Epac1 (cyclic AMP sensor) potentiation of Piezo2-mediated mechanotransduction contributes to mechanical allodynia during neuropathic pain, and the Epac-selective cAMP analogue 8-pCPT sensitizes mechanically evoked currents in sensory neurons.