S
Stephen F. Vatner
Researcher at Rutgers University
Publications - 96
Citations - 6520
Stephen F. Vatner is an academic researcher from Rutgers University. The author has contributed to research in topics: Heart failure & Cardiomyopathy. The author has an hindex of 40, co-authored 96 publications receiving 5952 citations. Previous affiliations of Stephen F. Vatner include University of Medicine and Dentistry of New Jersey.
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Journal ArticleDOI
Autophagy in chronically ischemic myocardium
Lin Yan,Dorothy E. Vatner,Song-Jung Kim,Hui Ge,Malthi Masurekar,William H. Massover,Guiping Yang,Yutaka Matsui,Junichi Sadoshima,Stephen F. Vatner +9 more
TL;DR: Testing the hypothesis that chronically ischemic myocardium induces autophagy, a cellular degradation process responsible for the turnover of unnecessary or dysfunctional organelles and cytoplasmic proteins, which could protect against the consequences of further ischemia found this mechanism to be a homeostatic mechanism.
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Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure
Fady I. Malik,James J. Hartman,Kathleen A. Elias,Bradley P. Morgan,Hector P. Rodriguez,Katjuša Brejc,Robert L. Anderson,Sandra H. Sueoka,Kenneth Lee,Jeffrey T. Finer,Roman Sakowicz,Ramesh Baliga,David R. Cox,Marc Garard,Guillermo Godinez,Raja Kawas,Erica Kraynack,David Lenzi,Pu Ping Lu,Alexander Muci,Congrong Niu,Xiangping Qian,Daniel W. Pierce,Maria Pokrovskii,Ion Suehiro,Sheila Sylvester,Todd Tochimoto,Corey Valdez,Wenyue Wang,Tatsuo Katori,David A. Kass,You Tang Shen,Stephen F. Vatner,David J. Morgans +33 more
TL;DR: It is shown that omecamtiv mecarbil binds to the myosin catalytic domain and operates by an allosteric mechanism to increase the transition rate of myOSin into the strongly actin-bound force-generating state.
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Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress
Lin Yan,Dorothy E. Vatner,J. Patrick O'Connor,Andreas S. Ivessa,Hui Ge,Wei Chen,Shinichi Hirotani,Yoshihiro Ishikawa,Junichi Sadoshima,Stephen F. Vatner +9 more
TL;DR: A significant activation of the Raf/MEK/ERK signaling pathway and upregulation of cell protective molecules, including superoxide dismutase are demonstrated and suggest that AC is a fundamentally important mechanism regulating lifespan and stress resistance.
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Silent Information Regulator 2α, a Longevity Factor and Class III Histone Deacetylase, Is an Essential Endogenous Apoptosis Inhibitor in Cardiac Myocytes
Ralph R. Alcendor,Lorrie A. Kirshenbaum,Shin-ichiro Imai,Stephen F. Vatner,Junichi Sadoshima +4 more
TL;DR: Ex vivo Sir2 expression was increased significantly in hearts from dogs with heart failure induced by rapid pacing superimposed on stable, severe hypertrophy, suggesting that Sir2 may play a cardioprotective role in pathologic hearts in vivo.
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Short Communication: Vascular Smooth Muscle Cell Stiffness As a Mechanism for Increased Aortic Stiffness With Aging
Hongyu Qiu,Yi Zhu,Yi Zhu,Zhe Sun,Jerome P. Trzeciakowski,Meredith Gansner,Christophe Depre,Ranillo R.G. Resuello,Filipinas F. Natividad,William C. Hunter,Guy M. Genin,Elliot L. Elson,Dorothy E. Vatner,Gerald A. Meininger,Stephen F. Vatner +14 more
TL;DR: In this paper, the authors tested the hypothesis that the mechanisms also involve intrinsic stiffening of vascular smooth muscle cells (VSMCs) and found that aortic stiffness increases by 200% in vivo.