Showing papers in "European Journal of Pharmaceutical Sciences in 2016"

TL;DR: Block co-polymeric micelles receive increased attention due to their ability to load therapeutics, deliver the cargo to the site of action, improve the pharmacokinetic of the loaded drug and reduce off-target cytotoxicity.

TL;DR: A clear knowledge is provided on the wide-ranging biological activities of 2-arylindoles over the past two decades, which would be beneficial for the designing of more potent drug targets in order to compete with the existing drugs.

TL;DR: This study indicates that certain grades of EVA were applicable feedstock material for 3D printing to produce drug-loaded implantable prototypes with the drug incorporated within the entire matrix of the medical devices.

TL;DR: Encouraging results proved that therapeutic concentrations of TFB could be transported directly to brain via olfactory pathway after intranasal administration of polymeric and lipidic nanoparticles.

TL;DR: Results suggested that Ap-MSN-DOX has the potential for the targeted delivery of therapeutic agents into EpCAM positive colon cancer cells to improve therapeutic index while reducing side effects.

TL;DR: Evaluated in vitro cellular efficacy results indicated enhanced uptake and efficacy of erlotinib loaded CSLPHNPs compared to erlotInib solution in A549 cells, a human lung adenocarcinoma cell line, and CSL PHNPs could be a potential delivery system for erlot inib in the therapy of NSCLC.

TL;DR: Five main parameters that have to be taken into account to avoid the degradation of folic acid are focused on: light, temperature, concentration, oxygen and pH, which are the most cited in the literature.

TL;DR: The investigated norfloxacin-loaded collagen/chitosan scaffold is a potential candidate for skin regeneration application and the tissue regeneration time was fast compared to non-treated wounds.

TL;DR: Molecular mechanisms and tumor microenvironment leading to decreased drug sensitivity, and strategies of reversing drug resistance are described.

TL;DR: This work describes an approach to modify the release of active compound from a 3D printed model drug product geometry intended for flexible dosing and precision medication, and shows the potential of custom-made, drug loaded feed materials for 3D printing of precision drug products with tailored drug release characteristics.

TL;DR: It is demonstrated how SP models can be used to predict the effects of multi-target interactions and of homeostatic feedback on the pharmacological response and it is concluded that incorporation of expressions to describe the interactions in biological network analysis opens new avenues to the understanding of the results of drug treatment on the fundamental aspects of biological systems behavior.

TL;DR: This PBPK model demonstrates the benefit of allowing for the complexities of passive permeability combined with active cellular uptake modulated by an electrochemical gradient and active efflux and recovery of the extent of the observed effect of cimetidine on metformin AUC.

TL;DR: Exipients can have an impact on the absorption, distribution, metabolism and elimination (ADME) processes of the co-administered drug, which is important information when selecting excipients for any new formulation.

TL;DR: Rutin-loaded nanoparticles are functionally characterized as a safe SPF enhancer in sunscreens, especially in association with UV filters, and had good performance on skin compatibility tests.

TL;DR: The results prove that these new formulations for antifungal econazole derivatives delivery are at least as active as commercially available formulations.

TL;DR: A fast screening process to assess the co-former feasibility in co-amorphous drug-AA blends has been developed on the basis of the amorphization kinetics upon oscillatory ball milling, suggesting that non-polar AAs, such as tryptophan, phenylalanine, leucine, isoleucines, methionine, valine and proline, are a good first choice in the selection of a co-formers for a given drug in

TL;DR: This thorough pre-formulation study represents an important advance towards the development of an efficient pre-anesthetic for use in dentistry.

TL;DR: A dual-functional glioma targeting delivery of doxorubicin based on the PAMAM G5 dendrimer, modified with folic acid (FA) to target tumor cell, also borneol (BO), a well known safe material derived from traditional Chinese medicine, to facilitate the BBB permeability and reduce the toxicity of naked PamAM is presented.

TL;DR: The mechanism of glucose reabsorption in the kidneys, the mechanism of action of SGLT2 inhibitors, several SGLt2 inhibitors currently available in the market as well as those in various phases of development, their individual pharmacokinetics as well and the discussion about the future role of S GLT2 inhibitor are covered.

TL;DR: In this paper, a QbD approach was used in the preparation of lipid nanoparticle formulations to improve skin penetration of 5-fluorouracil, a widely-used compound for treating non-melanoma skin cancer.

TL;DR: The preparation of chitosan nanoparticles in combination with pectins, as additional mucoadhesive biopolymers, was investigated, and the biocompatibility of the used materials was assessed by the chorioallantoic membrane assay, confirming the safety of the materials.

TL;DR: It has been established that the solubility of levofloxacin in these buffers is higher than that of the other fluoroquinolones.

TL;DR: In vitro release studies reveal that a drug release behavior is correlated with the size of the nanofibers, drug loading and matrix degradation after a specific time and ANN dissolution modeling showed increased correlation efficacy compared to MLR.

TL;DR: Oral perception of grittiness was increasingly perceived with increasing amount and size of particles and increasing viscosity of the administration media had a masking effect on the perception of particles.

TL;DR: Significantly higher brain/blood ratio of CH-ME in comparison to QF-ME and drug solution following intranasal administration revealed prolonged retention of QF at site of action suggesting superiority of CH as permeability enhancer.

TL;DR: The results from the current experimental study improved the understanding regarding the interplay between granulation time and the axial and solid-liquid mixing responsible for the granulation performance in twin-screw wet granulation.

TL;DR: Pharmacokinetic parameters after oral administration of 5-FU were improved by nanoencapsulation and Bioavailability, Cmax, Tmax, t1/2 and distribution volume were significantly improved, while clearance were decreased.

TL;DR: Dacetate and triacetate chitosan are novel polymers that can be used to formulate nanoparticles which efficiently encapsulated anticancer drugs, and sustained the release and enhanced tumor cellular uptake of these drugs.

TL;DR: The optimized ASDs batch were stable at 40°C, 75% RH for a period of 6months without any dissolution rate changes, and remained into amorphous state, according to observations inferred from DSC, XRD and in vitro dissolution studies.

TL;DR: SEDDS containing 8% DAP/DOA complex may be considered as a new potential oral delivery system for daptomycin exhibiting an anionic net charge and exhibiting also mucus permeating properties as well as a protective effect towards drug degradation by α-chymotrypsin.