L
Lina M. Moreno
Researcher at University of Iowa
Publications - 42
Citations - 4231
Lina M. Moreno is an academic researcher from University of Iowa. The author has contributed to research in topics: Genome-wide association study & Candidate gene. The author has an hindex of 23, co-authored 42 publications receiving 3798 citations. Previous affiliations of Lina M. Moreno include University of Antioquia.
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Journal ArticleDOI
Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes.
Shinji Kondo,Brian C. Schutte,Rebecca J. Richardson,Bryan C. Bjork,Alexandra S. Knight,Yoriko Watanabe,Emma Howard,Renata Lúcia Leite Ferreira de Lima,Sandra Daack-Hirsch,Achim Sander,Donna M. McDonald-McGinn,Elaine H. Zackai,Edward J. Lammer,Arthur S. Aylsworth,Holly H. Ardinger,Andrew C. Lidral,Barbara R. Pober,Lina M. Moreno,Mauricio Arcos-Burgos,Consuelo Valencia,Claude Houdayer,Michel Bahuau,Danilo Moretti-Ferreira,Antonio Richieri-Costa,Michael J. Dixon,Jeffrey C. Murray +25 more
TL;DR: It is demonstrated that haploinsufficiency of IRF6 disrupts orofacial development and are consistent with dominant-negative mutations disturbing development of the skin and genitalia.
Journal ArticleDOI
Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate.
Theresa M. Zucchero,Margaret E. Cooper,Brion S. Maher,Sandra Daack-Hirsch,Buena Nepomuceno,Lucilene Arilho Ribeiro,Diana Caprau,Kaare Christensen,Yasushi Suzuki,Junichiro Machida,Nagato Natsume,Koh-ichiro Yoshiura,Alexandre R. Vieira,Iêda M. Orioli,Eduardo E. Castilla,Lina M. Moreno,Mauricio Arcos-Burgos,Andrew C. Lidral,L. Leigh Field,You E. Liu,Ajit Kisor Ray,Toby H Goldstein,R. E. Schultz,Min Shi,Marla K. Johnson,Shinji Kondo,Brian C. Schutte,Mary L. Marazita,Jeffrey C. Murray,Jeffrey C. Murray +29 more
TL;DR: DNA-sequence variants associated with IRF6 are major contributors to cleft lip, with or without cleft palate; moreover, the results for some individual populations from South America and Asia were highly significant.
Journal ArticleDOI
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
Terri H. Beaty,Jeffrey C. Murray,Mary L. Marazita,Ronald G. Munger,Ingo Ruczinski,Jacqueline B. Hetmanski,Kung Yee Liang,Tao Wu,Tao Wu,Tanda Murray,M. Daniele Fallin,Richard A. Redett,Gerald V. Raymond,Holger Schwender,Sheng Chih Jin,Margaret E. Cooper,Martine Dunnwald,Maria A. Mansilla,Elizabeth J. Leslie,Stephen Bullard,Andrew C. Lidral,Lina M. Moreno,Renato Menezes,Alexandre R. Vieira,Aline Petrin,Allen J. Wilcox,Rolv T. Lie,Ethylin Wang Jabs,Ethylin Wang Jabs,Yah Huei Wu-Chou,Philip Kuo Ting Chen,Hong Wang,Xiaoqian Ye,Xiaoqian Ye,Shangzhi Huang,Vincent Yeow,Samuel S. Chong,Sun Ha Jee,Bing Shi,Kaare Christensen,Mads Melbye,Kimberly F. Doheny,Elizabeth W. Pugh,Hua Ling,Eduardo E. Castilla,Andrew E. Czeizel,Lian Ma,L. Leigh Field,Lawrence C. Brody,Faith Pangilinan,James L. Mills,Anne M. Molloy,Peadar N. Kirke,James M. Scott,Mauricio Arcos-Burgos,Alan F. Scott +55 more
TL;DR: In this paper, case-parent trios were used in a genome-wide association study of cleft lip with and without cleft palate, and two previously identified regions (at chromosome 8q24 and IRF6) attained genomewide significance.
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
Terri H. Beaty,Jeffrey C. Murray,Mary L. Marazita,Ronald G. Munger,Ingo Ruczinski,Jacqueline B. Hetmanski,Kung Yee Liang,Tao Wu,Tanda Murray,M. Daniele Fallin,Richard A. Redett,Gerald V. Raymond,Holger Schwender,Sheng Chih Jin,Margaret E. Cooper,Martine Dunnwald,Maria A. Mansilla,Elizabeth J. Leslie,Stephen Bullard,Andrew C. Lidral,Lina M. Moreno,Renato Menezes,Alexandre R. Vieira,Aline Petrin,Allen J. Wilcox,Rolv T. Lie,Ethylin Wang Jabs,Yah Huei Wu-Chou,Philip Kuo-Ting Chen,Hong Wang,Xiaoqian Ye,Shangzhi Huang,Vincent Yeow,Samuel S. Chong,Sun Ha Jee,Bing Shi,Kaare Christensen,Doheny Kimberly,W Pugh Elizabeth,Ling Hua,E Castilla Eduardo,Andrew E. Czeizel,Lian Ma,L. Leigh Field,Lawrence C. Brody,Faith Pangilinan,James L. Mills,Anne M. Molloy,Peadar N. Kirke,John M. Scott,Mauricio Arcos-Burgos,Alan F. Scott +51 more
TL;DR: Replication studies from several populations showed confirming evidence, with families of European ancestry giving strong evidence for markers in 8q24, whereas Asian families showed stronger evidence for association with MAFB and ABCA4, and expression studies support a role for MAFBs in palatal development.
Journal ArticleDOI
Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35
Mary L. Marazita,Jeffrey C. Murray,Andrew C. Lidral,Mauricio Arcos-Burgos,Margaret E. Cooper,Toby H Goldstein,Brion S. Maher,Sandra Daack-Hirsch,R. E. Schultz,M. Adela Mansilla,L. Leigh Field,You E. Liu,Natalie J. Prescott,Sue Malcolm,Robin M. Winter,Ajit Kisor Ray,Lina M. Moreno,Consuelo Valencia,Katherine Neiswanger,Diego F. Wyszynski,Joan E. Bailey-Wilson,Hasan Albacha-Hejazi,Terri H. Beaty,Iain McIntosh,Jacqueline B. Hetmanski,Gökhan Tunçbilek,Matthew S. Edwards,Louise A. Harkin,Rodney J. Scott,Laurence Roddick +29 more
TL;DR: These are the first genomewide significant linkage results ever reported for CL/P, and they represent an unprecedented demonstration of the power of linkage analysis to detect multiple genes simultaneously for a complex disorder.