M
Martine Dunnwald
Researcher at University of Iowa
Publications - 51
Citations - 2721
Martine Dunnwald is an academic researcher from University of Iowa. The author has contributed to research in topics: IRF6 & Keratinocyte. The author has an hindex of 20, co-authored 43 publications receiving 2454 citations. Previous affiliations of Martine Dunnwald include Roy J. and Lucille A. Carver College of Medicine & UAMS College of Medicine.
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Journal ArticleDOI
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
Terri H. Beaty,Jeffrey C. Murray,Mary L. Marazita,Ronald G. Munger,Ingo Ruczinski,Jacqueline B. Hetmanski,Kung Yee Liang,Tao Wu,Tao Wu,Tanda Murray,M. Daniele Fallin,Richard A. Redett,Gerald V. Raymond,Holger Schwender,Sheng Chih Jin,Margaret E. Cooper,Martine Dunnwald,Maria A. Mansilla,Elizabeth J. Leslie,Stephen Bullard,Andrew C. Lidral,Lina M. Moreno,Renato Menezes,Alexandre R. Vieira,Aline Petrin,Allen J. Wilcox,Rolv T. Lie,Ethylin Wang Jabs,Ethylin Wang Jabs,Yah Huei Wu-Chou,Philip Kuo Ting Chen,Hong Wang,Xiaoqian Ye,Xiaoqian Ye,Shangzhi Huang,Vincent Yeow,Samuel S. Chong,Sun Ha Jee,Bing Shi,Kaare Christensen,Mads Melbye,Kimberly F. Doheny,Elizabeth W. Pugh,Hua Ling,Eduardo E. Castilla,Andrew E. Czeizel,Lian Ma,L. Leigh Field,Lawrence C. Brody,Faith Pangilinan,James L. Mills,Anne M. Molloy,Peadar N. Kirke,James M. Scott,Mauricio Arcos-Burgos,Alan F. Scott +55 more
TL;DR: In this paper, case-parent trios were used in a genome-wide association study of cleft lip with and without cleft palate, and two previously identified regions (at chromosome 8q24 and IRF6) attained genomewide significance.
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
Terri H. Beaty,Jeffrey C. Murray,Mary L. Marazita,Ronald G. Munger,Ingo Ruczinski,Jacqueline B. Hetmanski,Kung Yee Liang,Tao Wu,Tanda Murray,M. Daniele Fallin,Richard A. Redett,Gerald V. Raymond,Holger Schwender,Sheng Chih Jin,Margaret E. Cooper,Martine Dunnwald,Maria A. Mansilla,Elizabeth J. Leslie,Stephen Bullard,Andrew C. Lidral,Lina M. Moreno,Renato Menezes,Alexandre R. Vieira,Aline Petrin,Allen J. Wilcox,Rolv T. Lie,Ethylin Wang Jabs,Yah Huei Wu-Chou,Philip Kuo-Ting Chen,Hong Wang,Xiaoqian Ye,Shangzhi Huang,Vincent Yeow,Samuel S. Chong,Sun Ha Jee,Bing Shi,Kaare Christensen,Doheny Kimberly,W Pugh Elizabeth,Ling Hua,E Castilla Eduardo,Andrew E. Czeizel,Lian Ma,L. Leigh Field,Lawrence C. Brody,Faith Pangilinan,James L. Mills,Anne M. Molloy,Peadar N. Kirke,John M. Scott,Mauricio Arcos-Burgos,Alan F. Scott +51 more
TL;DR: Replication studies from several populations showed confirming evidence, with families of European ancestry giving strong evidence for markers in 8q24, whereas Asian families showed stronger evidence for association with MAFB and ABCA4, and expression studies support a role for MAFBs in palatal development.
Journal ArticleDOI
Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 ( Irf6 )
Christopher R. Ingraham,Akira Kinoshita,Shinji Kondo,Baoli Yang,Samin A. Sajan,Kurt J. Trout,Margaret Malik,Martine Dunnwald,Stephen L. Goudy,Michael Lovett,Jeffrey C. Murray,Brian C. Schutte +11 more
TL;DR: It is reported that mice deficient for Irf6 have abnormal skin, limb and craniofacial development, and Histological and gene expression analyses indicate that the primary defect is in keratinocyte differentiation and proliferation.
Journal ArticleDOI
Dominant mutations in GRHL3 cause Van der Woude syndrome and disrupt oral periderm development
Myriam Peyrard-Janvid,Elizabeth J. Leslie,Youssef A. Kousa,Tiffany L. Smith,Martine Dunnwald,Måns Magnusson,Brian A. Lentz,Per Unneberg,Ingegerd Fransson,Hannele Koillinen,Jorma Rautio,Marie Pegelow,Agneta Karsten,Lina Basel-Vanagaite,Lina Basel-Vanagaite,William Gordon,Bogi Andersen,Thomas Svensson,Jeffrey C. Murray,Robert A. Cornell,Juha Kere,Juha Kere,Juha Kere,Brian C. Schutte +23 more
TL;DR: Data demonstrated that mutations in two genes, IRF6 and GRHL3, can lead to nearly identical phenotypes of orofacial cleft and supported the hypotheses that both genes are essential for the presence of a functional oral periderm and that failure of this process contributes to VWS.
Journal ArticleDOI
Biology of bone marrow-derived endothelial cell precursors.
TL;DR: It is concluded that expression of endothelial nitric oxide synthase may be the most reliable antigenic indicator of the phenotype and that those tumors in which bone marrow-derived cells will have a significant contribution and design therapies accordingly may be able to be predicted.