K
Ken Ichiro Kubo
Researcher at Keio University
Publications - 48
Citations - 3331
Ken Ichiro Kubo is an academic researcher from Keio University. The author has contributed to research in topics: Reelin & DAB1. The author has an hindex of 25, co-authored 48 publications receiving 2984 citations. Previous affiliations of Ken Ichiro Kubo include Jikei University School of Medicine & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development.
Atsushi Kamiya,Atsushi Kamiya,Ken Ichiro Kubo,Toshifumi Tomoda,Toshifumi Tomoda,Manabu Takaki,Richard Youn,Yuji Ozeki,Yuji Ozeki,Naoya Sawamura,Una Park,Chikako Kudo,Chikako Kudo,Masako Okawa,Christopher A. Ross,Mary E. Hatten,Kazunori Nakajima,Kazunori Nakajima,Akira Sawa +18 more
TL;DR: It is demonstrated that DISC1 is a component of the microtubule-associated dynein motor complex and is essential for maintaining the complex at the centrosome, hence contributing to normal microtubular dynamics and suggesting that loss of DISC 1 function may underlie neurodevelopmental dysfunction in schizophrenia.
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Rab GTPases-Dependent Endocytic Pathways Regulate Neuronal Migration and Maturation through N-Cadherin Trafficking
Takeshi Kawauchi,Takeshi Kawauchi,Takeshi Kawauchi,Katsutoshi Sekine,Mima Shikanai,Kaori Chihama,Kenji Tomita,Ken Ichiro Kubo,Kazunori Nakajima,Yo-ichi Nabeshima,Mikio Hoshino +10 more
TL;DR: It is shown that several Rab-dependent trafficking pathways differentially participate in neuronal migration, an essential step for the formation of the mammalian-specific six-layered brain structure.
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Knockdown of DISC1 by In Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral Deficits
Minae Niwa,Atsushi Kamiya,Rina Murai,Rina Murai,Ken Ichiro Kubo,Aaron J. Gruber,Kenji Tomita,Lingling Lu,Shuta Tomisato,Hanna Jaaro-Peled,Saurav Seshadri,Hideki Hiyama,Beverly Huang,Kazuhisa Kohda,Yukihiro Noda,Patricio O'Donnell,Kazunori Nakajima,Akira Sawa,Toshitaka Nabeshima,Toshitaka Nabeshima +19 more
TL;DR: The potential to generate an animal model via in utero gene transfer is reported to address an important question of how nonlethal deficits in early development may affect postnatal brain maturation and high brain functions in adulthood, which are impaired in various psychiatric illnesses such as schizophrenia.
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DISC1-dependent switch from progenitor proliferation to migration in the developing cortex
Koko Ishizuka,Atsushi Kamiya,Edwin C. Oh,Hiroaki Kanki,Saurav Seshadri,Jon F. Robinson,Hannah Murdoch,Allan J. Dunlop,Ken Ichiro Kubo,K. Furukori,Beverly Huang,Mariela Zeledon,Akiko Hayashi-Takagi,Hideyuki Okano,Kazunori Nakajima,Miles D. Houslay,Nicholas Katsanis,Akira Sawa +17 more
TL;DR: It is reported that phosphorylation of DISC1, a major susceptibility factor for several mental disorders, acts as a molecular switch from maintaining proliferation of mitotic progenitor cells to activating migration of postmitotic neurons in mice.
Journal ArticleDOI
Reelin controls neuronal positioning by promoting cell-matrix adhesion via inside-out activation of integrin α5β1
Katsutoshi Sekine,Takeshi Kawauchi,Takeshi Kawauchi,Ken Ichiro Kubo,Takao Honda,Joachim Herz,Joachim Herz,Mitsuharu Hattori,Tatsuo Kinashi,Kazunori Nakajima +9 more
TL;DR: It is shown that after Reelin binds to its receptors, it activates integrin α5β1 through the intracellular Dab1-Crk/CrkL-C3G-Rap1 pathway, which controls terminal translocation, which mediates proper neuronal alignments in the mature cortex.