Lisa Rinaldi

TL;DR: The development of an eosinophil-less mouse now permits an unambiguous assessment of a number of human diseases that have been linked to this granulocyte, including allergic diseases, parasite infections, and tumorigenesis.

TL;DR: An aerosolized fibrinolytic agent, tissue-type plasminogen activator, significantly diminished airwayhyperresponsiveness in mice with allergic airway inflammation, consistent with the hypothesis that leakage of fibrinogen and thrombin and their accumulation on the airway surface can contribute to the pathogenesis of airway hyperresponsiveness.

TL;DR: The results of this study support the conclusion that airway closure is a major component of hyperresponsiveness in allergically inflamed mice.

TL;DR: TGF-β1 protein levels were increased in OVA-challenged lungs versus naive controls, and airway epithelial cells were shown to be a likely source of TGF- β1, and the effects of blocking T GF-β signaling with neutralizing antibody were examined.

TL;DR: Differences between LVDI and HV suggest that an optimal frequency range of DI exists, within which the benefits of maintaining an open lung outweigh injury incurred from overdistention.