J
John F. Alcorn
Researcher at University of Pittsburgh
Publications - 127
Citations - 7028
John F. Alcorn is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Inflammation & Medicine. The author has an hindex of 39, co-authored 110 publications receiving 5986 citations. Previous affiliations of John F. Alcorn include Boston Children's Hospital & University of Vermont.
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Journal ArticleDOI
TH17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice
Laura McKinley,John F. Alcorn,Alanna C. Peterson,Rachel B. DuPont,Shernaaz B Kapadia,Alison J. Logar,Adam C. Henry,Charles G. Irvin,Jon D. Piganelli,Anuradha Ray,Jay K. Kolls +10 more
TL;DR: Both TH2 and TH17 cells are able to induce AHR, whereas TH17 cell-mediated airway inflammation and AHR are steroid resistant, indicating a potential role for TH 17 cells in steroid-resistant asthma.
Journal ArticleDOI
TH17 Cells in Asthma and COPD
TL;DR: It is shown that advanced COPD is characterized by lymphoid follicles, drawing attention to immunological mechanisms in COPD, and a potential role for T(H)17 cells in severe, steroid-insensitive asthma and COPD needs to be better defined.
Journal ArticleDOI
Critical Role of IL-17RA in Immunopathology of Influenza Infection
Christopher R. Crowe,Kong Chen,Derek Pociask,John F. Alcorn,Cameron Krivich,Richard I. Enelow,Ted M. Ross,Joseph L. Witztum,Jay K. Kolls +8 more
TL;DR: Data support targeting IL-17 orIL-17RA in acute lung injury due to acute viral infection and shows significantly reduced levels of oxidized phospholipids, which have previously been shown to be an important mediator in several models of acute Lung injury, including influenza infection and gastric acid aspiration.
Journal ArticleDOI
Influenza A Inhibits Th17-Mediated Host Defense against Bacterial Pneumonia in Mice
Anupa Kudva,Erich V. Scheller,Keven M. Robinson,Chris R. Crowe,Sun Mi Choi,Samantha Slight,Shabaana A. Khader,Patricia J. Dubin,Richard I. Enelow,Jay K. Kolls,Jay K. Kolls,John F. Alcorn +11 more
TL;DR: Data indicate a novel mechanism by which influenza A-induced type I IFNs inhibit Th17 immunity and increase susceptibility to secondary bacterial pneumonia.
Journal ArticleDOI
Interleukin-17 Is Required for T Helper 1 Cell Immunity and Host Resistance to the Intracellular Pathogen Francisella tularensis
Yinyao Lin,Shane Ritchea,Alison J. Logar,Samantha Slight,Michelle N. Messmer,Javier Rangel-Moreno,Lokesh Guglani,John F. Alcorn,Heather Strawbridge,Sang Mi Park,Reiko Onishi,Nikki Nyugen,Michael J. Walter,Derek Pociask,Troy D. Randall,Sarah L. Gaffen,Yoichiro Iwakura,Jay K. Kolls,Shabaana A. Khader +18 more
TL;DR: It is shown that the IL-23-Th17 pathway regulates theIL-12-Th1 cell pathway and was required for protective immunity against F.tularensis live vaccine strain and a biological function for IL-17A in regulating IL- 12-Th 1 cell immunity and host responses to an intracellular pathogen.