Lisheng Wang

TL;DR: A unique miRNA signature is identified that distinguishes NPMc+ mutated from the cytoplasmic-negative (NPM1 unmutated) cases and includes the up-regulation of miR-10a, miR -10b, several let-7 and miR –29 family members and support a role for miRNAs in the regulation of HOX genes in this leukemia subtype.

TL;DR: Novel mutations in c-CBL and CBL-b have been identified in human AML and may represent potential targets for novel therapeutics.

TL;DR: CDK4/6 can be a therapeutic target in Flt3 ITD AML but also in primary Flt 3 wt AML, and acquired resistance to CDK 4/6 inhibition can arise through activation CDK2.

TL;DR: Results show that FKBP12 binds to most of the rapalogs with high affinity (K(I) values in the nanomolar to low micromolar range), creating a large repertoire of composite surfaces for potential recognition of macromolecular targets such as proteins.

TL;DR: The data suggest that the activation of the INK4/CDK4,6/Rb/E2F pathway by Flt3 ITD has an essential role for proliferation and survival in AML cells, and PD-0332991 was neither cytotoxic nor cytostatic in THP-1 and U937 cells.