M
Massimo F. Martelli
Researcher at University of Perugia
Publications - 257
Citations - 20260
Massimo F. Martelli is an academic researcher from University of Perugia. The author has contributed to research in topics: Transplantation & Leukemia. The author has an hindex of 62, co-authored 243 publications receiving 18870 citations. Previous affiliations of Massimo F. Martelli include Ludwig Maximilian University of Munich.
Papers
More filters
Journal ArticleDOI
Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants
Loredana Ruggeri,Marusca Capanni,Elena Urbani,Katia Perruccio,Warren D. Shlomchik,Antonella Tosti,Sabrina Posati,Daniela Rogaia,Francesco Frassoni,Franco Aversa,Massimo F. Martelli,Andrea Velardi +11 more
TL;DR: It is shown that donor-versus-recipient natural killer (NK)–cell alloreactivity could eliminate leukemia relapse and graft rejection and protect patients against GVHD in human transplants and in mice, the pretransplant infusion of alloreactive NK cells obviated the need for high-intensity conditioning and reduced GV HD.
Journal ArticleDOI
Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype
Brunangelo Falini,Christina Mecucci,Enrico Tiacci,Myriam Alcalay,Roberto Rosati,Laura Pasqualucci,Roberta La Starza,Daniela Diverio,Emanuela Colombo,Antonella Santucci,Barbara Bigerna,Roberta Pacini,Alessandra Pucciarini,Arcangelo Liso,Marco Vignetti,Paola Fazi,Natalia Meani,Valentina Pettirossi,Giuseppe Saglio,Franco Mandelli,Francesco Lo-Coco,Pier Giuseppe Pelicci,Massimo F. Martelli +22 more
TL;DR: Cytoplasmic NPM is a characteristic feature of a large subgroup of patients with AML who have a normal karyotype, NPM gene mutations, and responsiveness to induction chemotherapy.
Journal ArticleDOI
Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
Mauro Di Ianni,Mauro Di Ianni,Franca Falzetti,Alessandra Carotti,Adelmo Terenzi,Flora Castellino,Elisabetta Bonifacio,Beatrice Del Papa,Tiziana Zei,Roberta Iacucci Ostini,Debora Cecchini,Teresa Aloisi,Katia Perruccio,Loredana Ruggeri,Chiara Balucani,Antonio Pierini,Paolo Sportoletti,Cynthia Aristei,Brunangelo Falini,Yair Reisner,Andrea Velardi,Franco Aversa,Massimo F. Martelli +22 more
TL;DR: It is shown for the first time in humans that adoptive transfer of Tregs prevented GVHD in the absence of any posttransplantation immunosuppression, promoted lymphoid reconstitution, improved immunity to opportunistic pathogens, and did not weaken the graft-versus-leukemia effect.
Journal ArticleDOI
Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype
Susanne Schnittger,Claudia Schoch,Wolfgang Kern,Cristina Mecucci,Claudia Tschulik,Massimo F. Martelli,Torsten Haferlach,Wolfgang Hiddemann,Brunangelo Falini +8 more
TL;DR: It is demonstrated that NPM1+/FLT3-LM- mutations are an independent predictor for a favorable outcome in AML with normal karyotype.
Journal ArticleDOI
Full Haplotype-Mismatched Hematopoietic Stem-Cell Transplantation: A Phase II Study in Patients With Acute Leukemia at High Risk of Relapse
Franco Aversa,Adelmo Terenzi,Antonio Tabilio,Franca Falzetti,Alessandra Carotti,Stelvio Ballanti,Rita Felicini,Flavio Falcinelli,Andrea Velardi,Loredana Ruggeri,Teresa Aloisi,Jean Pierre Saab,Antonella Santucci,Katia Perruccio,Maria Paola Martelli,Cristina Mecucci,Yair Reisner,Massimo F. Martelli +17 more
TL;DR: The mismatched-related transplant emerges as a viable, alternative source of stem cells for acute leukemia patients without matched donors and/or those who urgently need transplantation.