Liyan Lao

TL;DR: It is demonstrated that two cell-surface molecules, CD10 and GPR77, specifically define a CAF subset correlated with chemoresistance and poor survival in multiple cohorts of breast and lung cancer patients, and suggested that targeting the CD10+GPR77+ CAFs subset could be an effective therapeutic strategy against CSC-driven solid tumors.

TL;DR: It is demonstrated that the lncRNA NKILA is expressed by tumor-associated cytotoxic T cells, and this predisposes them to activation-induced cell death and escape of tumors from immunologically mediated destruction.

TL;DR: In this article, upregulation of regulator of G protein signaling (RGS)1 in helper TH1 cells and cytotoxic T lymphocytes (CTLs) was associated with shorter survival of patients with breast and lung cancer.

TL;DR: Analysis of BC patient cohorts and TCGA datasets identified f-PIK3Cδ (protein and mRNA levels) as an independent prognostic factor for overall and disease free survival, highlighting it as a therapeutic target for TNBC.

TL;DR: It is found that targeting IRENA in IFN-activated macrophages abrogated their protumor effects, while retaining their capacity to enhance antitumor immunity, and indicates that lncRNA can determine the dichotomy of inflammatory cells on cancer progression and antitumors immunity.