L
Liza Leventhal
Researcher at Rush University Medical Center
Publications - 10
Citations - 1641
Liza Leventhal is an academic researcher from Rush University Medical Center. The author has contributed to research in topics: Neuroprotection & Striatum. The author has an hindex of 7, co-authored 9 publications receiving 1605 citations.
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Journal ArticleDOI
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease.
Jeffrey H. Kordower,Marina E. Emborg,Jocelyne Bloch,Shuang Y. Ma,Yaping Chu,Liza Leventhal,Jodi L. McBride,Er-Yun Chen,Stéphane Palfi,Ben Roitberg,W. Douglas Brown,James E. Holden,Robert W. Pyzalski,Michael D. Taylor,Paul M. Carvey,Zaodung Ling,Didier Trono,Philippe Hantraye,Nicole Déglon,Patrick Aebischer,Patrick Aebischer +20 more
TL;DR: Data indicate that GDNF delivery using a lentiviral vector system can prevent nigrostriatal degeneration and induce regeneration in primate models of PD and might be a viable therapeutic strategy for PD patients.
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Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration
Stéphane Palfi,Stéphane Palfi,Liza Leventhal,Yaping Chu,Shuang Y. Ma,Marina E. Emborg,Roy A.E. Bakay,Nicole Déglon,Nicole Déglon,Philippe Hantraye,Patrick Aebischer,Patrick Aebischer,Jeffrey H. Kordower +12 more
TL;DR: Stereological counts of TH-ir striatal neurons in aged and parkinsonian nonhuman primates revealed that GDNF delivered via a lentiviral vector (lenti-) further increased the number of these cells, suggesting GDNF may mediate plasticity in the dopamine-depleted primate brain.
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Cyclosporin A protects striatal neurons in vitro and in vivo from 3-nitropropionic acid toxicity.
Liza Leventhal,Caryl E. Sortwell,Rose Hanbury,Timothy J. Collier,Jeffrey H. Kordower,Stéphane Palfi +5 more
TL;DR: CsA or more lipophilic analogues of this compound, may be of potential therapeutic benefit by protecting vulnerable neurons from the primary pathological event observed in HD.
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Delayed onset of progressive dystonia following subacute 3-nitropropionic acid treatment in Cebus apella monkeys.
Stéphane Palfi,Liza Leventhal,Christopher G. Goetz,Philippe Hantraye,Ben‐Zion Roitberg,Joe Sramek,Marina E. Emborg,Jeffrey H. Kordower +7 more
TL;DR: This novel primate model may be particularly useful for studying the structural changes underlying delayed and progressive manifestations of abnormal movements with the ultimate goal of facilitating the evaluation of novel therapeutic strategies.
Journal ArticleDOI
Excitotoxic and metabolic damage to the rodent striatum: role of the P75 neurotrophin receptor and glial progenitors.
Rose Hanbury,Vinod Charles,Er-Yun Chen,Liza Leventhal,Jeffrey M. Rosenstein,Elliott J. Mufson,Jeffrey H. Kordower +6 more
TL;DR: Striatal lesions created by means of excitotoxic or metabolic mechanisms trigger the expression of p75NTR in structures related to progenitor cells, indicating that these cells are newly born astrocytes.