M
Marina E. Emborg
Researcher at University of Wisconsin-Madison
Publications - 102
Citations - 5388
Marina E. Emborg is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: MPTP & Substantia nigra. The author has an hindex of 32, co-authored 92 publications receiving 4893 citations. Previous affiliations of Marina E. Emborg include Rush University Medical Center & University of Chicago.
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Journal ArticleDOI
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease.
Jeffrey H. Kordower,Marina E. Emborg,Jocelyne Bloch,Shuang Y. Ma,Yaping Chu,Liza Leventhal,Jodi L. McBride,Er-Yun Chen,Stéphane Palfi,Ben Roitberg,W. Douglas Brown,James E. Holden,Robert W. Pyzalski,Michael D. Taylor,Paul M. Carvey,Zaodung Ling,Didier Trono,Philippe Hantraye,Nicole Déglon,Patrick Aebischer,Patrick Aebischer +20 more
TL;DR: Data indicate that GDNF delivery using a lentiviral vector system can prevent nigrostriatal degeneration and induce regeneration in primate models of PD and might be a viable therapeutic strategy for PD patients.
Journal ArticleDOI
Age-Related Declines in Nigral Neuronal Function Correlate With Motor Impairments in Rhesus Monkeys
Marina E. Emborg,Shuang Y. Ma,Elliott J. Mufson,Allan I. Levey,Michael D. Taylor,W. Douglas Brown,James E. Holden,Jeffrey H. Kordower +7 more
TL;DR: The correlation of motor deficits with the loss of TH‐ir and DAT‐ir nigral neurons suggests that aged nonhuman primates may provide a useful model for mimicking changes seen in human aging and early Parkinson's disease.
Journal ArticleDOI
Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration
Stéphane Palfi,Stéphane Palfi,Liza Leventhal,Yaping Chu,Shuang Y. Ma,Marina E. Emborg,Roy A.E. Bakay,Nicole Déglon,Nicole Déglon,Philippe Hantraye,Patrick Aebischer,Patrick Aebischer,Jeffrey H. Kordower +12 more
TL;DR: Stereological counts of TH-ir striatal neurons in aged and parkinsonian nonhuman primates revealed that GDNF delivered via a lentiviral vector (lenti-) further increased the number of these cells, suggesting GDNF may mediate plasticity in the dopamine-depleted primate brain.
Journal ArticleDOI
Lentiviral gene transfer to the nonhuman primate brain.
Jeffrey H. Kordower,Jocelyne Bloch,Shuang Y. Ma,Yaping Chu,Stéphane Palfi,Ben Roitberg,Ben Roitberg,Marina E. Emborg,Philippe Hantraye,Nicole Déglon,Patrick Aebischer +10 more
TL;DR: Data indicate that robust transduction of striatal and nigral cells can occur in the nonhuman primate brain for up to 3 months, and studies are now ongoing testing the ability of lentivirus encoding for dopaminergic trophic factors to augment the nigrostriatal system in non human primate models of Parkinson's disease.
Journal ArticleDOI
Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial
Tanya Simuni,Karl Kieburtz,Barbara C. Tilley,Jordan J. Elm,Bernard Ravina,Debra Babcock,Marina E. Emborg,Robert A. Hauser,Cornelia Kamp,John C. Morgan,G. Webster Ross,David Simon,Jacci Bainbridge,Liana Baker,Ivan Bodis-Wollner,James T. Boyd,Franca Cambi,Julie H. Carter,Kelvin L. Chou,Nabila Dahodwala,Richard B. Dewey,Rohit Dhall,John Y. Fang,Buff Farrow,Andrew Feigin,Sofya Glazman,John L. Goudreau,Pauline LeBlanc,Stephen L. Lee,Maureen A. Leehey,Mark F. Lew,Stephanie Lowenhaupt,Sheng Luo,Rajesh Pahwa,Adriana Pérez,Jay S. Schneider,Burton L. Scott,Binit B. Shah,Kathleen M. Shannon,Saloni Sharma,Carlos Singer,Daniel D. Truong,Renee Wagner,Karen Williams,Anne-Marie Wills,Pei Shieen Wong,Pei Shieen Wong,Cindy Zadikoff,Richard M. Zweig +48 more
TL;DR: It is suggested that pioglitazone at the doses studied here is unlikely to modify progression in early Parkinson's disease.