L
Loïc Dragin
Researcher at Paris Descartes University
Publications - 3
Citations - 791
Loïc Dragin is an academic researcher from Paris Descartes University. The author has contributed to research in topics: SAMHD1 & Ubiquitin ligase. The author has an hindex of 3, co-authored 3 publications receiving 721 citations. Previous affiliations of Loïc Dragin include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Journal ArticleDOI
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates.
Hichem Lahouassa,Waaqo Daddacha,Henning Hofmann,Diana Ayinde,Diana Ayinde,Diana Ayinde,Eric C. Logue,Loïc Dragin,Loïc Dragin,Loïc Dragin,Nicolin Bloch,Claire Maudet,Claire Maudet,Claire Maudet,Matthieu Bertrand,Matthieu Bertrand,Matthieu Bertrand,Thomas Gramberg,Gianfranco Pancino,Stéphane Priet,Bruno Canard,Nadine Laguette,Monsef Benkirane,Catherine Transy,Catherine Transy,Catherine Transy,Nathaniel R. Landau,Baek Kim,Baek Kim,Florence Margottin-Goguet,Florence Margottin-Goguet,Florence Margottin-Goguet +31 more
TL;DR: It is found that SAMHD1 restricted infection by hydrolyzing intracellular deoxynucleoside triphosphates (dNTPs), lowering their concentrations to below those required for the synthesis of the viral DNA by reverse transcriptase (RT).
Journal ArticleDOI
HIV-1 Vpr Induces the Degradation of ZIP and sZIP, Adaptors of the NuRD Chromatin Remodeling Complex, by Hijacking DCAF1/VprBP
Claire Maudet,Adèle Sourisce,Loïc Dragin,Hichem Lahouassa,Jean-Christophe Rain,Serge Bouaziz,Serge Bouaziz,Bertha Cecilia Ramirez,Bertha Cecilia Ramirez,Bertha Cecilia Ramirez,Florence Margottin-Goguet,Florence Margottin-Goguet,Florence Margottin-Goguet +12 more
TL;DR: Two transcriptional regulators, ZIP and sZIP, are identified as Vpr-binding proteins degraded in the presence of Vpr, highlighting the existence of two host transcription factors inactivated by Vpr.
Journal ArticleDOI
Erratum: SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates (Nature Immunology (2012) 13 (223-228))
Hichem Lahouassa,Waaqo Daddacha,Henning Hofmann,Diana Ayinde,Eric C. Logue,Loïc Dragin,Nicolin Bloch,Claire Maudet,Matthieu Bertrand,Thomas Gramberg,Gianfranco Pancino,Stéphane Priet,Bruno Canard,Nadine Laguette,Monsef Benkirane,Catherine Transy,Nathaniel R. Landau,Baek Kim,Florence Margottin-Goguet +18 more
TL;DR: Hichem Lahouassa, Waaqo Daddacha, Henning Hofmann, Diana Ayinde, Eric C Logue, Loïc Dragin, Nicolin Bloch, Claire Maudet, Matthieu Bertrand, Thomas Gramberg, Gianfranco Pancino, Stéphane Priet, Bruno Canard, Nadine Laguette, Monsef Benkirane, Catherine Transy, Nathaniel R Landau, Baek