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Nadine Laguette
Researcher at University of Montpellier
Publications - 33
Citations - 3887
Nadine Laguette is an academic researcher from University of Montpellier. The author has contributed to research in topics: Sting & Medicine. The author has an hindex of 12, co-authored 22 publications receiving 3491 citations. Previous affiliations of Nadine Laguette include Centre national de la recherche scientifique.
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Journal ArticleDOI
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
Nadine Laguette,Bijan Sobhian,Nicoletta Casartelli,Mathieu Ringeard,Christine Chable-Bessia,Emmanuel Ségéral,Ahmad Yatim,Stéphane Emiliani,Olivier Schwartz,Monsef Benkirane +9 more
TL;DR: It is demonstrated that SAMHD1 is an antiretroviral protein expressed in cells of the myeloid lineage that inhibits an early step of the viral life cycle, and is probably required for HIV-1 restriction.
Journal ArticleDOI
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates.
Hichem Lahouassa,Waaqo Daddacha,Henning Hofmann,Diana Ayinde,Diana Ayinde,Diana Ayinde,Eric C. Logue,Loïc Dragin,Loïc Dragin,Loïc Dragin,Nicolin Bloch,Claire Maudet,Claire Maudet,Claire Maudet,Matthieu Bertrand,Matthieu Bertrand,Matthieu Bertrand,Thomas Gramberg,Gianfranco Pancino,Stéphane Priet,Bruno Canard,Nadine Laguette,Monsef Benkirane,Catherine Transy,Catherine Transy,Catherine Transy,Nathaniel R. Landau,Baek Kim,Baek Kim,Florence Margottin-Goguet,Florence Margottin-Goguet,Florence Margottin-Goguet +31 more
TL;DR: It is found that SAMHD1 restricted infection by hydrolyzing intracellular deoxynucleoside triphosphates (dNTPs), lowering their concentrations to below those required for the synthesis of the viral DNA by reverse transcriptase (RT).
Journal ArticleDOI
HIV-1 Tat Assembles a Multifunctional Transcription Elongation Complex and Stably Associates with the 7SK snRNP
Bijan Sobhian,Nadine Laguette,Ahmad Yatim,Mirai Nakamura,Yves Levy,Rosemary Kiernan,Monsef Benkirane +6 more
TL;DR: The purified HIV-1 Tat-associated factors from HeLa nuclear extract are purified and show that Tat forms two distinct and stable complexes, Tatcom1 and Tatcom2, which are important for P-TEFb function.
Journal ArticleDOI
Phosphorylation of SAMHD1 by Cyclin A2/CDK1 Regulates Its Restriction Activity toward HIV-1
Alexandra Cribier,Benjamin Descours,Ana Luiza Chaves Valadão,Nadine Laguette,Monsef Benkirane +4 more
TL;DR: The results uncover the phosphorylation of SAMHD1 at Thr592 by cyclin A2/CDK1 as a key regulatory mechanism of its antiviral activity.
Journal ArticleDOI
SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells.
Benjamin Descours,Alexandra Cribier,Christine Chable-Bessia,Diana Ayinde,Gillian I. Rice,Yanick J. Crow,Ahmad Yatim,Olivier Schwartz,Nadine Laguette,Monsef Benkirane +9 more
TL;DR: The identification of SAMHD1 as the restriction factor preventing efficient viral DNA synthesis in non-cycling resting CD4+ T-cells could impact the understanding of HIV-1 mediated CD4-cell depletion and establishment of the viral reservoir, two of the HIV/AIDS hallmarks.