H
Henning Hofmann
Researcher at Robert Koch Institute
Publications - 18
Citations - 1527
Henning Hofmann is an academic researcher from Robert Koch Institute. The author has contributed to research in topics: SAMHD1 & Viral replication. The author has an hindex of 14, co-authored 18 publications receiving 1390 citations. Previous affiliations of Henning Hofmann include Carnegie Institution for Science & Paul Ehrlich Institute.
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Journal ArticleDOI
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates.
Hichem Lahouassa,Waaqo Daddacha,Henning Hofmann,Diana Ayinde,Diana Ayinde,Diana Ayinde,Eric C. Logue,Loïc Dragin,Loïc Dragin,Loïc Dragin,Nicolin Bloch,Claire Maudet,Claire Maudet,Claire Maudet,Matthieu Bertrand,Matthieu Bertrand,Matthieu Bertrand,Thomas Gramberg,Gianfranco Pancino,Stéphane Priet,Bruno Canard,Nadine Laguette,Monsef Benkirane,Catherine Transy,Catherine Transy,Catherine Transy,Nathaniel R. Landau,Baek Kim,Baek Kim,Florence Margottin-Goguet,Florence Margottin-Goguet,Florence Margottin-Goguet +31 more
TL;DR: It is found that SAMHD1 restricted infection by hydrolyzing intracellular deoxynucleoside triphosphates (dNTPs), lowering their concentrations to below those required for the synthesis of the viral DNA by reverse transcriptase (RT).
Journal ArticleDOI
Restriction of diverse retroviruses by SAMHD1
Thomas Gramberg,Tanja Kahle,Nicolin Bloch,Sabine Wittmann,Erik Müllers,Waaqo Daddacha,Henning Hofmann,Baek Kim,Dirk Lindemann,Nathaniel R. Landau +9 more
TL;DR: The results suggest that SAMHD1 has broad anti-retroviral activity against which most viruses have not found an escape, including the alpha, beta and gamma classes.
Journal ArticleDOI
The Vpx Lentiviral Accessory Protein Targets SAMHD1 for Degradation in the Nucleus
Henning Hofmann,Eric C. Logue,Nicolin Bloch,Waaqo Daddacha,Sylvie B. Polsky,Megan L. Schultz,Baek Kim,Nathaniel R. Landau +7 more
TL;DR: Findings suggest that SAMHD1 is targeted by Vpx for ubiquitination and degradation in the nucleus.
Journal ArticleDOI
Species-specific inhibition of APOBEC3C by the prototype foamy virus protein bet.
Mario Perkovic,Stanislaw Schmidt,Daniela Marino,Rebecca A. Russell,Benjamin Stauch,Henning Hofmann,Henning Hofmann,Ferdinand Kopietz,Björn-Philipp Kloke,Jörg Zielonka,Jörg Zielonka,Heike Ströver,Johannes Hermle,Dirk Lindemann,Vinay K. Pathak,Gisbert Schneider,Martin Löchelt,Klaus Cichutek,Carsten Münk,Carsten Münk +19 more
TL;DR: The hypothesis that Bet inhibits incorporation of APOBEC3Cs into retroviral particles likely achieves this by trapping APOBec3C protein in complexes rendering them unavailable for newly generated viruses due to direct immobilization is supported.
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HERVs New Role in Cancer: From Accused Perpetrators to Cheerful Protectors
TL;DR: Both the detrimental and the new beneficial role of HERV reactivation in terms of its implications for cancer are discussed.