Nicolin Bloch

TL;DR: It is found that SAMHD1 restricted infection by hydrolyzing intracellular deoxynucleoside triphosphates (dNTPs), lowering their concentrations to below those required for the synthesis of the viral DNA by reverse transcriptase (RT).

TL;DR: The biology of the restriction factors APOBEC3, SAMHD1 and tetherin and the viral accessory proteins that counteract them are discussed and the roles of the accessory proteins are revealed.

TL;DR: The results suggest that SAMHD1 has broad anti-retroviral activity against which most viruses have not found an escape, including the alpha, beta and gamma classes.

TL;DR: Findings suggest that SAMHD1 is targeted by Vpx for ubiquitination and degradation in the nucleus.

TL;DR: Mutation of amino acids in the predicted DNA binding groove prevented substrate binding, confirming the role of this groove in substrate binding and shed light on how APOBEC3 proteins bind their substrate and determine which sites to deaminate.