F
Florence Margottin-Goguet
Researcher at University of Paris
Publications - 40
Citations - 2935
Florence Margottin-Goguet is an academic researcher from University of Paris. The author has contributed to research in topics: Ubiquitin ligase & SAMHD1. The author has an hindex of 19, co-authored 37 publications receiving 2650 citations. Previous affiliations of Florence Margottin-Goguet include Paris Descartes University & Centre national de la recherche scientifique.
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Journal ArticleDOI
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates.
Hichem Lahouassa,Waaqo Daddacha,Henning Hofmann,Diana Ayinde,Diana Ayinde,Diana Ayinde,Eric C. Logue,Loïc Dragin,Loïc Dragin,Loïc Dragin,Nicolin Bloch,Claire Maudet,Claire Maudet,Claire Maudet,Matthieu Bertrand,Matthieu Bertrand,Matthieu Bertrand,Thomas Gramberg,Gianfranco Pancino,Stéphane Priet,Bruno Canard,Nadine Laguette,Monsef Benkirane,Catherine Transy,Catherine Transy,Catherine Transy,Nathaniel R. Landau,Baek Kim,Baek Kim,Florence Margottin-Goguet,Florence Margottin-Goguet,Florence Margottin-Goguet +31 more
TL;DR: It is found that SAMHD1 restricted infection by hydrolyzing intracellular deoxynucleoside triphosphates (dNTPs), lowering their concentrations to below those required for the synthesis of the viral DNA by reverse transcriptase (RT).
Journal ArticleDOI
Vpu Antagonizes BST-2–Mediated Restriction of HIV-1 Release via β-TrCP and Endo-Lysosomal Trafficking
Richard S. Mitchell,Chris Katsura,Mark Skasko,Katie L Fitzpatrick,David Lau,Autumn Ruiz,Edward B. Stephens,Florence Margottin-Goguet,Florence Margottin-Goguet,Richard Benarous,John C. Guatelli,John C. Guatelli +11 more
TL;DR: The data support a model in which Vpu co-opts the β-TrCP/SCF E3 ubiquitin ligase complex to induce endosomal trafficking events that remove BST-2 from its site of action as a virion-tethering factor.
Journal ArticleDOI
HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase.
Erwann Le Rouzic,Nadia Belaïdouni,E. Estrabaud,Marina Morel,Jean-Christophe Rain,Catherine Transy,Florence Margottin-Goguet +6 more
TL;DR: This work shows that recruitment of DCAF1/VprBP by Vpr is essential for its cytostatic activity, and suggests that both proteins have evolved to preserve interaction with the same Cul4 ubiquitin ligase while diverging in the recognition of host substrates targeted for proteasomal degradation.
Journal ArticleDOI
ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase.
Irina Lassot,Emmanuel Ségéral,Clarisse Berlioz-Torrent,Hervé Durand,Lionel Groussin,Tsonwin Hai,Richard Benarous,Florence Margottin-Goguet +7 more
TL;DR: The F-box-deleted βTrCP protein behaves as a negative transdominant mutant that inhibits ATF4 ubiquitination and degradation and, subsequently, enhances its activity in cyclic AMP-mediated transcription.
Journal ArticleDOI
Human TRIM Gene Expression in Response to Interferons
Laetitia Carthagena,Anna Bergamaschi,Joseph M. Luna,Annie David,Pradeep D. Uchil,Florence Margottin-Goguet,Florence Margottin-Goguet,Walther Mothes,Uriel Hazan,Uriel Hazan,Uriel Hazan,Catherine Transy,Catherine Transy,Gianfranco Pancino,Sébastien Nisole,Sébastien Nisole,Sébastien Nisole +16 more
TL;DR: The results present the first comprehensive TRIM gene expression analysis in primary human immune cells, and suggest the involvement of additional TRIM proteins in regulating host antiviral activities.