Long Jun Wu

TL;DR: Recent progress on the physiology, pharmacology and pathophysiological function of mammalian TRP channels is reviewed to indicate that these channels have broad function in physiology.

TL;DR: It is reported that the activation of the NR2B and NR2A subunits of the NMDA receptor is critical for the induction of cingulate LTP, regardless of the induction protocol.

TL;DR: The results elucidate the molecular mechanisms underlying microglia–neuron communication that may be potentially neuroprotective in the epileptic brain and found that P2Y12 KO mice exhibited reduced seizure-induced increases in microglial process numbers and worsened KA-induced seizure behaviors.

TL;DR: It is reported that peripheral nerve injury triggered long-term changes in excitatory synaptic transmission in layer II/III neurons within the anterior cingulate cortex (ACC) and that AC1 is critical for such long- term changes.

TL;DR: It is demonstrated that FMR1 knock-out mice show a defect in trace fear memory without changes in locomotion, anxiety, and pain sensitivity, which suggests that synaptic plasticity in the ACC and amygdala of F MR1 KO mice plays an important role in the expression of behavioral phenotypes similar to the symptoms of fragile X syndrome.