L
Long Lin
Researcher at Chinese Academy of Sciences
Publications - 5
Citations - 403
Long Lin is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Autophagy & ATG8. The author has an hindex of 4, co-authored 5 publications receiving 354 citations. Previous affiliations of Long Lin include Beijing Normal University.
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Journal ArticleDOI
The WD40 Repeat PtdIns(3)P-Binding Protein EPG-6 Regulates Progression of Omegasomes to Autophagosomes
Qun Lu,Peiguo Yang,Xinxin Huang,Wanqiu Hu,Bin Guo,Fan Wu,Long Lin,Attila L. Kovács,Li Yu,Hong Zhang +9 more
TL;DR: It is demonstrated that autophagic PtdIns(3)P effectors play distinct roles in autophagosome formation and also provides a framework for understanding the concerted action of autophagy genes in protein aggregate degradation.
Journal ArticleDOI
Guidelines for monitoring autophagy in Caenorhabditis elegans
Hong Zhang,Jessica T. Chang,Bin Guo,Malene Hansen,Kailiang Jia,Attila L. Kovács,Caroline Kumsta,Louis R. Lapierre,Renaud Legouis,Long Lin,Qun Lu,Alicia Meléndez,Eyleen J. O’Rourke,Ken Sato,Miyuki Sato,Xiaochen Wang,Fan Wu +16 more
TL;DR: C. elegans is emerging as a powerful model organism to monitor autophagic levels while evaluating important physiological roles for autophagy in key developmental events as well as during adulthood.
Journal ArticleDOI
The scaffold protein EPG-7 links cargo-receptor complexes with the autophagic assembly machinery
TL;DR: To increase the efficiency of aggrephagy, specific scaffold proteins such as EPG-7 endow cargo specificity and link cargo–receptor complexes to the autophagic machinery.
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The composition of a protein aggregate modulates the specificity and efficiency of its autophagic degradation.
TL;DR: The results indicate that the composition and organization of protein aggregates provide another layer of regulation to modulate degradation efficiency.
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LSY-2 is essential for maintaining the germ-soma distinction in C. elegans
TL;DR: It is demonstrated that loss of function of the zinc-finger gene lsy-2 results in various somatic cells adopting germ cells characteristics, including expression of germline-specific P granules, enhanced RNAi activity and transgene silencing.