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Xinxin Huang
Researcher at Indiana University
Publications - 57
Citations - 2576
Xinxin Huang is an academic researcher from Indiana University. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 21, co-authored 53 publications receiving 2122 citations. Previous affiliations of Xinxin Huang include Fudan University & Beijing Normal University.
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Journal ArticleDOI
C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms
Ye Tian,Zhipeng Li,Wanqiu Hu,Haiyan Ren,E Tian,Yu Zhao,Qun Lu,Xinxin Huang,Peiguo Yang,Xin Li,Xiaochen Wang,Attila L. Kovács,Li Yu,Hong Zhang +13 more
TL;DR: This study establishes C. elegans as a multicellular genetic model to delineate the autophagy pathway and provides mechanistic insights into the metazoan-specific autophagic process.
Journal ArticleDOI
Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock.
Charlie Mantel,Heather O'Leary,Brahmananda R. Chitteti,Xinxin Huang,Scott Cooper,Giao Hangoc,Nickolay Brustovetsky,Edward F. Srour,Man Ryul Lee,Man Ryul Lee,Steve Messina-Graham,David M. Haas,Nadia Falah,Reuben Kapur,Louis M. Pelus,Nabeel Bardeesy,Julien Fitamant,Mircea Ivan,Kye Seong Kim,Hal E. Broxmeyer +19 more
TL;DR: In this article, the extraphysiologic oxygen shock/stress (EPHOSS) phenomenon was found to decrease the recovery of long-term repopulating HSCs and increase progenitor cells.
Journal ArticleDOI
SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress.
TL;DR: A role for SIRT1 in regulating autophagy and mitochondria function in ESCs upon oxidative stress, effects mediated at least in part by the class III PI3K/Beclin 1 and mTOR pathways is suggested.
SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress
TL;DR: SIRT1, an NAD-dependent deacetylase, plays a role in regulation of autophagy and has been linked to age-related reactive oxygen species (ROS) generation, which is highly dependent on mitochondrial metabolism as mentioned in this paper.
Journal ArticleDOI
The WD40 Repeat PtdIns(3)P-Binding Protein EPG-6 Regulates Progression of Omegasomes to Autophagosomes
Qun Lu,Peiguo Yang,Xinxin Huang,Wanqiu Hu,Bin Guo,Fan Wu,Long Lin,Attila L. Kovács,Li Yu,Hong Zhang +9 more
TL;DR: It is demonstrated that autophagic PtdIns(3)P effectors play distinct roles in autophagosome formation and also provides a framework for understanding the concerted action of autophagy genes in protein aggregate degradation.