Lorenzo Piemonti

TL;DR: It is found that CXCR1/2 chemokine receptors and their ligands are crucial negative determinants for islet survival after transplantation and should be a target for intervention to improve the efficacy of transplantation.

TL;DR: In this paper, the authors investigated the relationship between insulin resistance and cardiovascular disease in middle-aged women, including 53 patients with type 2 diabetes, 42 with impaired glucose tolerance, and 112 with normal glucose tolerance.

TL;DR: It is demonstrated that rapamycin directly affects human nTreg function in vivo, which consists of refitting their suppressive activity, whereas it does not directly change effector T-cell function.

TL;DR: Alterations in β-cell ADCY5 expression and impaired glucose signaling provide a likely route through which ADCy5 gene polymorphisms influence fasting glucose levels and T2D risk, while exerting more minor effects on incretin action.

TL;DR: A review of alternative sites used for islet transplantation in experimental animal models to provide improved engraftment and long-term survival minimizing surgical complications discusses site-specific benefits and drawbacks taking into account immunologic, metabolic, and technical aspects to identify the ideal microenvironment forIslet function and survival.