L
Lorna W. Harries
Researcher at University of Exeter
Publications - 161
Citations - 14837
Lorna W. Harries is an academic researcher from University of Exeter. The author has contributed to research in topics: Gene & Alternative splicing. The author has an hindex of 45, co-authored 155 publications receiving 13468 citations. Previous affiliations of Lorna W. Harries include University of Sussex & Ninewells Hospital.
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Journal ArticleDOI
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
Timothy M. Frayling,Nicholas J. Timpson,Michael N. Weedon,Eleftheria Zeggini,Eleftheria Zeggini,Eleftheria Zeggini,Rachel M. Freathy,Cecilia M. Lindgren,John R. B. Perry,Katherine S. Elliott,Katherine S. Elliott,Hana Lango,Nigel W. Rayner,Nigel W. Rayner,Nigel W. Rayner,Beverley M. Shields,Lorna W. Harries,Jeffrey C. Barrett,Jeffrey C. Barrett,Sian Ellard,Christopher J. Groves,Christopher J. Groves,Bridget A. Knight,Ann-Marie Patch,Andy R Ness,Shah Ebrahim,Debbie A Lawlor,Susan M. Ring,Yoav Ben-Shlomo,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Ulla Sovio,Ulla Sovio,Amanda J. Bennett,Amanda J. Bennett,David Melzer,Luigi Ferrucci,Ruth J. F. Loos,Inês Barroso,Nicholas J. Wareham,Fredrik Karpe,Fredrik Karpe,Katharine R. Owen,Katharine R. Owen,Lon R. Cardon,Mark Walker,Graham A. Hitman,Graham A. Hitman,Colin N. A. Palmer,Colin N. A. Palmer,Alex S. F. Doney,Alex S. F. Doney,Andrew D. Morris,George Davey Smith,Andrew T. Hattersley,Mark I. McCarthy +55 more
TL;DR: A genome-wide search for type 2 diabetes–susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI).
Journal ArticleDOI
Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
Eleftheria Zeggini,Michael N. Weedon,Cecilia M. Lindgren,Timothy M. Frayling,Katherine S. Elliott,Hana Lango,Nicholas J. Timpson,John R. B. Perry,Nigel W. Rayner,Rachel M. Freathy,Jeffrey C. Barrett,Beverley M. Shields,Andrew P. Morris,Sian Ellard,Christopher J. Groves,Lorna W. Harries,Jonathan Marchini,Katharine R. Owen,Beatrice Knight,Lon R. Cardon,Mark Walker,Graham A. Hitman,Andrew D. Morris,Alex S. F. Doney,Mark I. McCarthy,Andrew T. Hattersley +25 more
TL;DR: These findings provide insight into the genetic architecture of type 2 diabetes, emphasizing the contribution of multiple variants of modest effect and underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 1 diabetes.
Journal ArticleDOI
Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer.
TL;DR: A novel PCR assay has been developed which demonstrates that these two variant cDNAs represent distinct GSTP 1 alleles (GSTP1a and GSTP1b), which are found to be strongly associated with bladder cancer and testicular cancer and in prostate cancer a highly significant decrease was observed.
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Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease
Katie Lunnon,Rebecca G. Smith,Eilis Hannon,Philip L. De Jager,Gyan Srivastava,Manuela Volta,Claire Troakes,Safa Al-Sarraj,Joe Burrage,Ruby Macdonald,Daniel Condliffe,Lorna W. Harries,Pavel Katsel,Vahram Haroutunian,Zachary Kaminsky,C Joachim,John Powell,Simon Lovestone,David A. Bennett,Leonard C. Schalkwyk,Jonathan Mill +20 more
TL;DR: This study represents, to the best of the knowledge, the first epigenome-wide association study of AD employing a sequential replication design across multiple tissues and highlights the power of this approach for identifying methylomic variation associated with complex disease.
Journal ArticleDOI
Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk.
David Ryberg,Vidar Skaug,A Hewer,David H. Phillips,Lorna W. Harries,C R Wolf,D Ogreid,A Ulvik,P Vu,Aage Haugen +9 more
TL;DR: The results consistently indicated that the GSTM1 null genotype was associated with a slightly increased lung cancer risk and patients with the combination null and AG or GG had significantly higher adduct levels than all other genotype combinations.