Pavel Katsel

TL;DR: This study represents, to the best of the knowledge, the first epigenome-wide association study of AD employing a sequential replication design across multiple tissues and highlights the power of this approach for identifying methylomic variation associated with complex disease.

TL;DR: Therapeutic preservation of neuronal PGC-1alpha expression promotes the nonamyloidogenic processing of amyloid precursor protein precluding the generation of ameloidogenic Abeta peptides.

TL;DR: This cohort study generated large-scale matched multi-Omics data in AD and control brains for exploring novel molecular underpinnings of AD through whole genome sequencing, whole exome sequencing, transcriptome sequencing and proteome profiling data.

TL;DR: Using microarray technology to study 17 brain regions from subjects with varying severity of AD and dementia, multiple gene expression abnormalities of the key enzymes that control sphingolipid metabolism were detected and were correlated with the progression of clinical dementia.

TL;DR: This transcriptomic network analysis of 19 brain regions provides a comprehensive assessment of the critical molecular pathways associated with AD pathology and offers new insights into molecular mechanisms underlying selective regional vulnerability to AD at different stages of the progression of cognitive compromise and development of the canonical neuropathological lesions of AD.