K
Karsten Tedin
Researcher at Free University of Berlin
Publications - 74
Citations - 4915
Karsten Tedin is an academic researcher from Free University of Berlin. The author has contributed to research in topics: Salmonella enterica & Enterococcus faecium. The author has an hindex of 28, co-authored 68 publications receiving 4399 citations. Previous affiliations of Karsten Tedin include University of Texas at Austin & University of Vienna.
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Journal ArticleDOI
Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan
Stephen E. Girardin,Ivo G. Boneca,Leticia A.M. Carneiro,Aude Antignac,Muguette Jéhanno,Jérôme Viala,Karsten Tedin,Muhamed-Kheir Taha,Agnès Labigne,Ulrich Zähringer,Anthony J. Coyle,Peter S. DiStefano,John Bertin,Philippe J. Sansonetti,Dana J. Philpott +14 more
TL;DR: It is shown that human Nod1 specifically detects a unique diaminopimelate-containing N-acetylglucosamine–N-acetelmuramic acid tripeptide motif found in Gram-negative bacterial peptidoglycan, resulting in activation of the transcription factor NF-κB pathway.
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The RNA chaperone Hfq is essential for the virulence of Salmonella typhimurium
TL;DR: Hfq is involved in the expression and secretion of virulence factors in the facultative intracellular pathogen, Salmonella typhimurium, and appears to cause a chronic activation of the RpoE‐mediated envelope stress response which is likely due to a misregulation of membrane protein expression.
Journal ArticleDOI
Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine
Peter Schierack,Marcel Nordhoff,Marion Pollmann,Karl Dietrich Weyrauch,Salah Amasheh,Ulrike Lodemann,Jörg Jores,Babila Tachu,Sylvia Kleta,Anthony T. Blikslager,Karsten Tedin,Lothar H. Wieler +11 more
TL;DR: The permanent porcine intestinal epithelial cell line, IPEC-J2, is characterized using a variety of methods to assess the usefulness of this cell line as an in vitro infection model and concludes that it provides a relevant in vitro model system for porCine intestinal pathogen–host cell interactions.
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Influence of a probiotic Enterococcus faecium strain on development of the immune system of sows and piglets
Lydia Scharek,J. Guth,Katja Reiter,Karl Dietrich Weyrauch,David Taras,Peter Schwerk,Peter Schierack,Michael F.G. Schmidt,Lothar H. Wieler,Karsten Tedin +9 more
TL;DR: A remarkable decline in the frequency of beta-haemolytic and O141 serovars of Escherichia coli was observed in the intestinal contents of probiotic piglets, suggesting an explanation for the reduction in cytotoxic T-cell populations.
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A small non-coding RNA of the invasion gene island (SPI-1) represses outer membrane protein synthesis from the Salmonella core genome.
TL;DR: The first regulatory RNA of an enterobacterial pathogenicity island is identified, and new roles for Hfq and HilD in SPI‐1 gene expression are found, and InvR represses the synthesis of the abundant OmpD porin encoded by the Salmonella core genome.