M
Marie-France Martin-Eauclaire
Researcher at Aix-Marseille University
Publications - 68
Citations - 2853
Marie-France Martin-Eauclaire is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Scorpion toxin & Kaliotoxin. The author has an hindex of 28, co-authored 68 publications receiving 2664 citations. Previous affiliations of Marie-France Martin-Eauclaire include Centre national de la recherche scientifique.
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Journal ArticleDOI
A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies.
Jan Tytgat,K. George Chandy,Maria L. Garcia,George A. Gutman,Marie-France Martin-Eauclaire,Jurg van der Walt,Lourival D. Possani +6 more
TL;DR: In this paper, the classification of K + channel blocking peptides belonging to family 2 peptides and comprising 30-40 amino acids linked by three or four disulfide bridges is discussed.
Journal ArticleDOI
Kaliotoxin, a novel peptidyl inhibitor of neuronal BK-type Ca(2+)-activated K+ channels characterized from Androctonus mauretanicus mauretanicus venom.
Marcel Crest,G. Jacquet,Maurice Gola,H Zerrouk,A Benslimane,Hervé Rochat,Pascal Mansuelle,Marie-France Martin-Eauclaire +7 more
TL;DR: Electrophysiological experiments performed in identified nerve cells from the mollusc Helix pomatia showed that KTX specifically suppressed the whole cell Ca(2+)-activated K+ current, and comparison of KTX and CTX sequences leads to the identification of a short amino acid sequence which may be implicated in the toxin-channel interaction.
Journal ArticleDOI
Scorpion toxins affecting sodium current inactivation bind to distinct homologous receptor sites on rat brain and insect sodium channels
Dalia Gordon,Marie-France Martin-Eauclaire,Sandrine Cestèle,Charles Kopeyan,Edmond Carlier,Rym Ben Khalifa,Marcel Pelhate,Hervé Rochat +7 more
TL;DR: The presence of a cluster of receptor sites for scorpion toxins that inhibit sodium current inactivation, which is very similar on insect and rat brain sodium channels, in spite of the structural and pharmacological differences between them is suggested.
Journal ArticleDOI
Structural basis of α-scorpion toxin action on Nav channels
Thomas Clairfeuille,Alexander Cloake,Alexander Cloake,Daniel T. Infield,José P. Llongueras,Christopher P. Arthur,Zhong Rong Li,Yuwen Jian,Marie-France Martin-Eauclaire,Pierre E. Bougis,Claudio Ciferri,Christopher A. Ahern,Frank Bosmans,David H. Hackos,Alexis Rohou,Jian Payandeh +15 more
TL;DR: Structures reveal how activation of voltage-gated sodium channels causes conformational changes in a voltage-sensor domain, leading to fast inactivation, and pharmacological trapping of VSD4 reveals state-dependent interactions of gating charges from the S4 helix and S4-S5 linker.
Journal ArticleDOI
A structural link between inactivation and block of a K+ channel.
Christian Ader,Robert Schneider,Sönke Hornig,Phanindra Velisetty,Erica M. Wilson,Adam Lange,Karin Giller,Iris Ohmert,Marie-France Martin-Eauclaire,Dirk Trauner,Stefan Becker,Olaf Pongs,Marc Baldus +12 more
TL;DR: The results establish a structural link between inactivation and block of a K+ channel in a membrane setting using solid-state NMR spectroscopy in direct reference to electrophysiological and pharmacological experiments.