Luc Perrin

TL;DR: It is demonstrated that APOBEC3G exerts its antiviral effect during reverse transcription to trigger G-to-Ahypermutation in the nascent retroviral DNA, suggesting that hypermutation by editing is a general innate defence mechanism against this important group of pathogens.

TL;DR: Hematitis C virus and active intravenous drug use could be important factors in the morbidity and mortality among HIV-1-infected patients, possibly through impaired CD4-cell recovery in HCV seropositive patients receiving potent antiretroviral therapy.

TL;DR: In this paper, the authors determined the baseline rate of drug resistance in 2208 therapy-naive patients recently and chronically infected with HIV-1 from 19 European countries during 1996-2002.

TL;DR: The transmission of drug-resistant variants among individuals with primary HIV-1 infection is assessed and to introduce the best antiretroviral treatment, resistance testing should be done in recently HIV- 1-infected individuals.

TL;DR: In this article, a longitudinally analyzed study of 2235 participants of the Swiss HIV Cohort, commencing HAART between 1996 and 1997, showed that the CD4 Tlymphocyte count increase, the percentage of individuals with a CD4T-cell count of 500/μL or greater and less than 200μL, and the determinants of CD4-cell recovery were evaluated in individuals treated with continuous (CONT; n=985) and discontinuous (DISCONT, n=1250) HAART.