Luca Agnelli

TL;DR: The integrative analysis based on computational target prediction and miRNA/mRNA profiling defined a network of putative functional miRNA-target regulatory relations supported by expression data that were found significantly associated with the altered expression of miRNAs located in the involved regions.

TL;DR: This work finds pervasive DNA damage in hematologic malignancies, including multiple myeloma, lymphoma and leukemia, which leads to activation of a p53-independent, proapoptotic network centered on nuclear relocalization of ABL1 kinase, and identifies a new synthetic-lethal strategy to selectively target cancer cells presenting with endogenous DNA damage and low YAP1 levels.

TL;DR: It is proved that an experimentally controlled and functionally validated GEP analysis represents a powerful tool to identify novel pathogenetic networks and validate biologically suitable target genes for therapeutic interventions.

TL;DR: A crucial role of MALAT1 in the regulation of the proteasome machinery is demonstrated, and proof-of-concept that its targeting is a novel powerful option for the treatment of MM is provided.

TL;DR: It is proved that experimentally controlled GEP in ALCL cell lines represents a powerful tool to identify meaningful signaling networks for the recognition of systemic primary T-NHL.