W
W. Michael Kuehl
Researcher at National Institutes of Health
Publications - 72
Citations - 11363
W. Michael Kuehl is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Multiple myeloma & Monoclonal gammopathy of undetermined significance. The author has an hindex of 41, co-authored 71 publications receiving 10761 citations. Previous affiliations of W. Michael Kuehl include Cornell University & Walter Reed Army Institute of Research.
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Journal ArticleDOI
Frequent Engagement of the Classical and Alternative NF-κB Pathways by Diverse Genetic Abnormalities in Multiple Myeloma
Christina M. Annunziata,R. Eric Davis,Yulia N. Demchenko,William T. Bellamy,Ana Gabrea,Fenghuang Zhan,Georg Lenz,Ichiro Hanamura,George E. Wright,Wenming Xiao,Sandeep S. Dave,Elaine M. Hurt,Bruce K. Tan,Hong Zhao,Owen W. Stephens,Madhumita Santra,David R. Williams,Lenny Dang,Bart Barlogie,John D. Shaughnessy,W. Michael Kuehl,Louis M. Staudt +21 more
TL;DR: It is demonstrated that addiction to the NF-kappaB pathway is frequent in myeloma and suggest that IKKbeta inhibitors hold promise for the treatment of this disease.
Journal ArticleDOI
Multiple myeloma: evolving genetic events and host interactions
TL;DR: Multiple myeloma is a neoplasm of terminally differentiated B cells (plasma cells) in which chromosome translocations frequently place oncogenes under the control of immunoglobulin enhancers.
Journal ArticleDOI
Genetics and Cytogenetics of Multiple Myeloma A Workshop Report
Rafael Fonseca,Bart Barlogie,Régis Bataille,Christian Bastard,P. Leif Bergsagel,Marta Chesi,Faith E. Davies,Johannes Drach,Philip R. Greipp,Ilan R. Kirsch,W. Michael Kuehl,Jesus M. Hernandez,Stephane Minvielle,Linda M. Pilarski,John D. Shaughnessy,A. Keith Stewart,Hervé Avet-Loiseau,Hervé Avet-Loiseau +17 more
TL;DR: This summary describes the consensus recommendations arising from that meeting with special emphasis on novel genetic observations and Gene expression platforms capable of detecting many of the genetic aberrations found in the clonal cells of myeloma.
Journal ArticleDOI
Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma
P. Leif Bergsagel,W. Michael Kuehl,Fenghuang Zhan,Jeffrey R. Sawyer,Bart Barlogie,John D. Shaughnessy +5 more
TL;DR: Using gene expression profiling to identify 5 recurrent translocations, specific trisomies, and expression of cyclin D genes, MM tumors can be divided into 8 TC (translocation/cyclin D) groups that appear to be defined by early, and perhaps initiating, oncogenic events.
Journal ArticleDOI
Advances in biology of multiple myeloma: clinical applications
TL;DR: Delineation of the mechanisms mediating MM cell proliferation, survival, and migration in the bone marrow (BM) microenvironment may both enhance understanding of pathogenesis and provide the framework for identification and validation of novel molecular targets.