L
Luigia Lombardi
Researcher at University of Milan
Publications - 71
Citations - 3984
Luigia Lombardi is an academic researcher from University of Milan. The author has contributed to research in topics: Gene expression profiling & Gene. The author has an hindex of 35, co-authored 71 publications receiving 3854 citations. Previous affiliations of Luigia Lombardi include Columbia University & New York University.
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Journal ArticleDOI
B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50
Antonino Neri,Antonino Neri,Chih Chao Chang,Luigia Lombardi,Mauro Salina,Paolo Corradini,Anna Teresa Maiolo,R. S. K. Chaganti,Riccardo Dalla-Favera +8 more
TL;DR: The lyt -10 gene defines a new subfamily (rel/poly-G/ankyrin) of NF-κB-rel transcription factors with potential for oncogenic activation in human cancer.
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Pathogenesis of Burkitt lymphoma: Expression of an activated c-myc oncogene causes the tumorigenic conversion of EBV-infected human B lymphoblasts
TL;DR: EBV infection and c-myc activation are sufficient for the tumorigenic conversion of human B cells in vitro, strongly supporting the hypothesis that these same two pathogenetic steps may be involved in the in vivo development of Burkitt lymphoma.
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Identification of microRNA expression patterns and definition of a microRNA/mRNA regulatory network in distinct molecular groups of multiple myeloma
Marta Lionetti,Marta Biasiolo,Luca Agnelli,Katia Todoerti,Laura Mosca,Sonia Fabris,Gabriele Sales,Giorgio Lambertenghi Deliliers,Silvio Bicciato,Luigia Lombardi,Stefania Bortoluzzi,Antonino Neri +11 more
TL;DR: The integrative analysis based on computational target prediction and miRNA/mRNA profiling defined a network of putative functional miRNA-target regulatory relations supported by expression data that were found significantly associated with the altered expression of miRNAs located in the involved regions.
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A novel chromosomal translocation t(4; 14)(p16.3; q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene.
Raffaella Richelda,Raffaella Richelda,Raffaella Richelda,Domenica Ronchetti,Domenica Ronchetti,Domenica Ronchetti,Luca Baldini,Luca Baldini,Luca Baldini,Lilla Cro,Lilla Cro,Lilla Cro,Luigi Viggiano,Luigi Viggiano,Luigi Viggiano,R. Marzella,R. Marzella,R. Marzella,Mariano Rocchi,Mariano Rocchi,Mariano Rocchi,Takemi Otsuki,Takemi Otsuki,Takemi Otsuki,Luigia Lombardi,Luigia Lombardi,Luigia Lombardi,Anna Teresa Maiolo,Anna Teresa Maiolo,Anna Teresa Maiolo,Antonino Neri,Antonino Neri,Antonino Neri +32 more
TL;DR: Findings indicate that the t(4; 14)(p16.3; q32) represents a novel, recurrent chromosomal translocation in MM, and suggest that the FGFR3 gene may be the target of this abnormality and thus contribute to tumorigenesis in MM.
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Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and Bcl2A1 as critical target genes
Roberto Piva,Elisa Pellegrino,Michela Mattioli,Luca Agnelli,Luigia Lombardi,Francesco Boccalatte,Giulia Costa,Bruce Ruggeri,Mangeng Cheng,Roberto Chiarle,Giorgio Palestro,Antonino Neri,Giorgio Inghirami +12 more
TL;DR: It is proved that an experimentally controlled and functionally validated GEP analysis represents a powerful tool to identify novel pathogenetic networks and validate biologically suitable target genes for therapeutic interventions.