L
Luca Albergante
Researcher at University of Dundee
Publications - 32
Citations - 1173
Luca Albergante is an academic researcher from University of Dundee. The author has contributed to research in topics: Gene & Curse of dimensionality. The author has an hindex of 11, co-authored 31 publications receiving 700 citations. Previous affiliations of Luca Albergante include University of Milan & University of York.
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Journal ArticleDOI
Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer.
Yann Kieffer,Yann Kieffer,Hocine Rachid Hocine,Hocine Rachid Hocine,Géraldine Gentric,Géraldine Gentric,Floriane Pelon,Floriane Pelon,Charles Bernard,Charles Bernard,Brigitte Bourachot,Brigitte Bourachot,Sonia Lameiras,Luca Albergante,Luca Albergante,Claire Bonneau,Claire Bonneau,Claire Bonneau,Alice Guyard,Karin Tarte,Andrei Zinovyev,Andrei Zinovyev,Sylvain Baulande,Gérard Zalcman,Gérard Zalcman,Gérard Zalcman,Anne Vincent-Salomon,Fatima Mechta-Grigoriou,Fatima Mechta-Grigoriou +28 more
TL;DR: This study highlights a positive feedback loop between specific CAF-S1 clusters and Tregs and uncovers their role in immunotherapy resistance.
Journal ArticleDOI
Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM
Huidong Chen,Luca Albergante,Luca Albergante,Jonathan Y. Hsu,Jonathan Y. Hsu,Caleb A. Lareau,Caleb A. Lareau,Giosuè Lo Bosco,Jihong Guan,Shuigeng Zhou,Alexander N. Gorban,Daniel E. Bauer,Daniel E. Bauer,Martin J. Aryee,Martin J. Aryee,David M. Langenau,Andrei Zinovyev,Jason D. Buenrostro,Jason D. Buenrostro,Gengyang Yuan,Luca Pinello,Luca Pinello +21 more
TL;DR: STREAM is a pipeline for reconstruction and visualization of differentiation trajectories from both single-cell RNA-seq and ATAC-seq data and its utility for understanding myoblast differentiation and disentangling known heterogeneity in hematopoiesis for different organisms is demonstrated.
Journal ArticleDOI
Thymic involution and rising disease incidence with age
TL;DR: The immunological model featured here captures risk profiles for many cancer types and infectious diseases, and provides mechanistic insight into cancer emergence, suggesting that age-related decline in T cell output is a major risk factor.
Journal ArticleDOI
Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells
Alberto Moreno,Jamie T. Carrington,Luca Albergante,Mohammed Al Mamun,Emma J. Haagensen,Eirini-Stavroula Komseli,Vassilis G. Gorgoulis,Timothy J. Newman,J. Julian Blow +8 more
TL;DR: It is shown that complementary strand synthesis in early mitosis, ultrafine anaphase bridges, and G1-specific p53-binding protein 1 (53BP1) nuclear bodies provide a mechanism for resolving unreplicated DNA at DFSs in human cells.
Journal ArticleDOI
Robust and Scalable Learning of Complex Intrinsic Dataset Geometry via ElPiGraph
Luca Albergante,Evgeny M. Mirkes,Jonathan Bac,Huidong Chen,Huidong Chen,Alexis Martin,Louis Faure,Emmanuel Barillot,Emmanuel Barillot,Luca Pinello,Luca Pinello,Alexander N. Gorban,Andrei Zinovyev,Andrei Zinovyev +13 more
TL;DR: ElPiGraph exploits and further develops the concept of elastic energy, the topological graph grammar approach, and a gradient descent-like optimization of the graph topology, and is capable of approximating data point clouds via principal graph ensembles.