Caleb A. Lareau

TL;DR: An approach to identify disease-relevant tissues and cell types by analyzing gene expression data together with genome-wide association study (GWAS) summary statistics and found significant tissue-specific enrichments for 34 traits.

TL;DR: A simple activity-by-contact model substantially outperformed previous methods at predicting the complex connections in the CRISPR dataset and allows systematic mapping of enhancer–gene connections in a given cell type, on the basis of chromatin-state measurements.

TL;DR: A chromatin accessibility landscape of human hematopoiesis is constructed and variation consistent with lineage bias toward different developmental branches in multipotent cell types is found, providing a framework for integrative exploration of complex regulatory dynamics in a primary human tissue at single-cell resolution.

TL;DR: This work computationally infer chromatin potential as a quantitative measure of chromatin lineage-priming and use it to predict cell fate outcomes, and develops simultaneous high-throughput ATAC and RNA expression with sequencing (SHARE-seq), a highly scalable approach for measurement of Chromatin accessibility and gene expression in the same single cell.

TL;DR: It is shown that a CBE with rat APOBEC1 can cause extensive transcriptome-wide deamination of RNA cytosines in human cells, inducing tens of thousands of C-to-U edits and the need to more fully define and characterize the RNA off-target effects of deaminase enzymes in base editor platforms is suggested.