L
Lucia Natarelli
Researcher at Ludwig Maximilian University of Munich
Publications - 24
Citations - 785
Lucia Natarelli is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: microRNA & Inflammation. The author has an hindex of 12, co-authored 21 publications receiving 602 citations.
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Journal ArticleDOI
Correction: Corrigendum: Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4
Petra Hartmann,Zhe Zhou,Lucia Natarelli,Yuanyuan Wei,Maliheh Nazari-Jahantigh,Mengyu Zhu,Jochen Grommes,Sabine Steffens,Christian Weber,Andreas Schober +9 more
TL;DR: This Article contains an error in the dose of LNA-target site blocker oligonucleotides that was administered.
Journal ArticleDOI
Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4.
Petra Hartmann,Zhe Zhou,Lucia Natarelli,Yuanyuan Wei,Maliheh Nazari-Jahantigh,Mengyu Zhu,Jochen Grommes,Sabine Steffens,Christian Weber,Andreas Schober,Andreas Schober +10 more
TL;DR: This study suggests that Dicer promotes endothelial maladaptation and atherosclerosis in part by miR-103-mediated suppression of KLF4.
Journal ArticleDOI
Dicer in Macrophages Prevents Atherosclerosis by Promoting Mitochondrial Oxidative Metabolism.
Yuanyuan Wei,Judit Corbalán-Campos,Rashmi Gurung,Lucia Natarelli,Mengyu Zhu,Nicole Exner,Florian Erhard,Florian Erhard,Franziska Greulich,Claudia Geißler,N. Henriette Uhlenhaut,Ralf Zimmer,Andreas Schober +12 more
TL;DR: Dicer plays an atheroprotective role by coordinately regulating the inflammatory response and lipid metabolism in macrophages through enhancing fatty acid–fueled mitochondrial respiration, suggesting that promoting Dicer/miR-10a–dependent metabolic reprogramming in macophages has potential therapeutic implications to prevent atherosclerosis.
Journal ArticleDOI
Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis
Donato Santovito,Virginia Egea,Kiril Bidzhekov,Lucia Natarelli,André Mourão,Xavier Blanchet,Kanin Wichapong,Maria Aslani,Coy Brunßen,Michael Horckmans,Michael Horckmans,Michael Hristov,Arie Geerlof,Esther Lutgens,Esther Lutgens,Mat J.A.P. Daemen,Tilman M. Hackeng,Christian Ries,Triantafyllos Chavakis,Henning Morawietz,Ronald Naumann,Philipp von Hundelshausen,Sabine Steffens,Johan Duchene,Remco T. A. Megens,Remco T. A. Megens,Michael Sattler,Christian Weber +27 more
TL;DR: It is shown that miR-126-5p sustains endothelial integrity in the context of high shear stress and autophagy, and reveals a noncanonical mechanism by which miRNAs can modulate protein function.
Journal ArticleDOI
miR-103 promotes endothelial maladaptation by targeting lncWDR59.
Lucia Natarelli,Claudia Geißler,Gergely Csaba,Yuanyuan Wei,Mengyu Zhu,Andrea di Francesco,Andrea di Francesco,Petra Hartmann,Ralf Zimmer,Andreas Schober,Andreas Schober +10 more
TL;DR: It is shown that hyperlipidemia- and oxLDL-induced upregulation of miR-103 inhibits EC proliferation and promotes endothelial DNA damage through targeting of novel lncWDR59, which may promote atherosclerosis.