L
Lucía Otero
Researcher at University of the Republic
Publications - 49
Citations - 1701
Lucía Otero is an academic researcher from University of the Republic. The author has contributed to research in topics: Trypanosoma cruzi & Ruthenium. The author has an hindex of 24, co-authored 46 publications receiving 1542 citations. Previous affiliations of Lucía Otero include Pasteur Institute.
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Journal ArticleDOI
ESR, electrochemical and reactivity studies of antitrypanosomal palladium thiosemicarbazone complexes.
Lucía Otero,Christian Folch,Germán Barriga,Carolina Rigol,Lucía Opazo,Marisol Vieites,Dinorah Gambino,Hugo Cerecetto,Ester Norambuena,Claudio Olea-Azar +9 more
TL;DR: The stoichiometry of the complexes does not seem to affect significantly the hyperfine constants however the authors observed great differences between 5-nitrofurane and 5-Nitrofurylacroleine derivatives.
Journal ArticleDOI
Electrochemical and ESR study of 5-nitrofuryl-containing thiosemicarbazones antiprotozoal drugs.
Carolina Rigol,Claudio Olea-Azar,Fernando Mendizabal,Lucía Otero,Dinorah Gambino,Mercedes González,Hugo Cerecetto +6 more
TL;DR: The theoretical study exhibited an unusual assignment of the spin densities showing a free radical centered in the thiosemicarbazone moiety rather than the nitro which are in agreement with the experimental hyperfine pattern.
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Adjustments, extinction, and remains of selenocysteine incorporation machinery in the nematode lineage
Lucía Otero,Laura Romanelli-Cedrez,Anton A. Turanov,Vadim N. Gladyshev,Antonio Miranda-Vizuete,Gustavo Salinas +5 more
TL;DR: This study provides evidence of noncanonical translation initiation in C. elegans, not previously known for this well-established animal model, and provides key insights into Sec incorporation and the evolution of Sec utilization trait, selenoproteomes, seLenoproteins, and Sec residues.
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Antitumor and antiparasitic activity of novel ruthenium compounds with polycyclic aromatic ligands.
Helena Guiset Miserachs,Micaella Cipriani,Jordi Mas Grau,Marta Vilaseca,Julia Lorenzo,Andrea Medeiros,Marcelo A. Comini,Dinorah Gambino,Lucía Otero,Virtudes Moreno +9 more
TL;DR: Five novel ruthenium(II)-arene complexes with polycyclic aromatic ligands were synthesized, and complex 1 was the most potent antitumoral agent, showing high selectivity towards the parasites (selectivity index >100).
Journal ArticleDOI
Effect of the metal ion on the anti T. cruzi activity and mechanism of action of 5-nitrofuryl-containing thiosemicarbazone metal complexes
Micaella Cipriani,Jeannette Toloza,Lara Bradford,Eugenia Putzu,Marisol Vieites,Estela Curbelo,Ana Isabel Tomaz,Beatriz Garat,Juan Guerrero,Jorge S. Gancheff,Juan Diego Maya,Claudio Olea Azar,Dinorah Gambino,Lucía Otero +13 more
TL;DR: In this paper, the authors reported the development of palladium and platinum metal complexes with 5-nitrofuryl-containing thiosemicarbazones (L) as bioactive ligands against T. cruzi and PTA (1,3,5-triaza-7-phosphaadamantane) as co-ligand.