L
Lucien Fabre
Researcher at McGill University
Publications - 9
Citations - 288
Lucien Fabre is an academic researcher from McGill University. The author has contributed to research in topics: Bacterial outer membrane & Periplasmic space. The author has an hindex of 6, co-authored 9 publications receiving 210 citations. Previous affiliations of Lucien Fabre include Université de Montréal & University of British Columbia.
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Journal ArticleDOI
The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution.
Michael Carlson,John W. Young,Zhiyu Zhao,Lucien Fabre,Daniel Jun,Daniel Jun,Jianing Li,Jun Li,Harveer Singh Dhupar,Irvin Wason,Allan Mills,J. Thomas Beatty,John S. Klassen,Isabelle Rouiller,Franck Duong +14 more
TL;DR: The peptidisc method is rapid and cost-effective, and it may emerge as a universal tool for high-throughput stabilization of membrane proteins to advance modern biological studies.
Journal ArticleDOI
Structure–Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis
Juan Manuel Belardinelli,Amira Yazidi,Liang Yang,Lucien Fabre,Lucien Fabre,Wei Li,Benoit Jacques,Shiva K. Angala,Isabelle Rouiller,Isabelle Rouiller,Helen I. Zgurskaya,Jurgen Sygusch,Mary Jackson +12 more
TL;DR: The combined genetic, biochemical, and biophysical studies indicate that MmpL3 and CmpL1 are structurally similar to Gram-negative resistance-nodulation and division efflux pumps and that multiresistance to these inhibitors is enabled by conformational changes in MMPL3.
Journal ArticleDOI
Membrane Protein Complex ExbB4-ExbD1-TonB1 from Escherichia coli Demonstrates Conformational Plasticity
Aleksandr Sverzhinsky,Jacqueline W. Chung,Justin C. Deme,Lucien Fabre,Kristian T. Levey,Maria Plesa,David M. Carter,Patrick Lypaczewski,James W. Coulton +8 more
TL;DR: In vitro evidence is demonstrated of the first report for purification of the ExbB-ExbD-TonB complex, molar ratios within the complex, and structural biology that provides insights into 3D organization are presented.
Peer ReviewDOI
Author response: The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution
Michael Carlson,John W. Young,Zhiyu Zhao,Lucien Fabre,Daniel Jun,Daniel Jun,Jianing Li,Jun Li,Harveer Singh Dhupar,Irvin Wason,Allan Mills,J. Thomas Beatty,John S. Klassen,Isabelle Rouiller,Franck Duong +14 more
Journal ArticleDOI
Coordinated rearrangements between cytoplasmic and periplasmic domains of the membrane protein complex ExbB-ExbD of Escherichia coli.
Aleksandr Sverzhinsky,Lucien Fabre,Andrew L. Cottreau,Damien M.P. Biot-Pelletier,Sofia Khalil,Mihnea Bostina,Isabelle Rouiller,James W. Coulton +7 more
TL;DR: Copurified ExbB with ExbD as an ∼240 kDa protein-detergent complex, measured by light scattering and by native gels to reconstruct the particles in three structural states followed by sorting of the single particles and refinement of each state.