L
Lucy J. Newbury
Researcher at Cardiff University
Publications - 10
Citations - 425
Lucy J. Newbury is an academic researcher from Cardiff University. The author has contributed to research in topics: Cancer & Glycosaminoglycan. The author has an hindex of 6, co-authored 10 publications receiving 332 citations. Previous affiliations of Lucy J. Newbury include King's College London.
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Journal ArticleDOI
Mutations in TJP2 cause progressive cholestatic liver disease
Melissa Sambrotta,Sandra Strautnieks,Efterpi Papouli,Peter Rushton,Barnaby Clark,David A. Parry,Clare V. Logan,Lucy J. Newbury,Binita M. Kamath,Simon C. Ling,Tassos Grammatikopoulos,Tassos Grammatikopoulos,Bart E. Wagner,John C. Magee,Ronald J. Sokol,Giorgina Mieli-Vergani,Giorgina Mieli-Vergani,Joshua D. Smith,Colin A. Johnson,Patricia McClean,Michael A. Simpson,A. S. Knisely,Laura N. Bull,Richard J. Thompson,Richard J. Thompson +24 more
TL;DR: It is shown that protein-truncating mutations in the tight junction protein 2 gene (TJP2) cause failure of protein localization and disruption of tight-junction structure, leading to severe cholestatic liver disease.
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Association of elevated urinary miR-126, miR-155, and miR-29b with diabetic kidney disease
Cristina Beltrami,Katherine Simpson,Mark Jesky,Alexa Wonnacott,Christopher P. Carrington,Peter Holmans,Lucy J. Newbury,Robert H. Jenkins,Thomas P O Ashdown,Colin M. Dayan,Simon C. Satchell,Peter Corish,Paul Cockwell,Donald James Fraser,Timothy Bowen +14 more
TL;DR: An altered urinary miRNA profile associated with DKD is revealed and variations to miRNA release from GEnCs are linked to miRNAs detected in GEnC conditioned medium in response to tumor necrosis factor-α and transforming growth factor-β1.
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Electrochemical detection of urinary microRNAs via sulfonamide-bound antisense hybridisation
TL;DR: A modified glassy carbon electrochemical sensor for microRNAs was developed and the electrode allowed detection of femtomolar concentrations of miR-21 and the method was applied to detection of urinary miR -21.
Journal ArticleDOI
Stabilization of Urinary MicroRNAs by Association with Exosomes and Argonaute 2 Protein.
Cristina Beltrami,Aled Clayton,Lucy J. Newbury,Peter Corish,Robert H. Jenkins,Aled O. Phillips,Donald James Fraser,Timothy Bowen +7 more
TL;DR: Association with exosomes and AGO2 stabilized urinary miRNAs, suggesting quantitative urinary miRNA analysis has the potential to identify novel, non-invasive CKD biomarkers.
Journal ArticleDOI
A urinary microRNA panel that is an early predictive biomarker of delayed graft function following kidney transplantation.
Usman Khalid,Lucy J. Newbury,Katherine Simpson,Robert H. Jenkins,Timothy Bowen,Lucy Bates,Lucy Bates,Neil S. Sheerin,Neil S. Sheerin,Rafael Chavez,Rafael Chavez,Donald James Fraser +11 more
TL;DR: Urinary microRNAs evaluated as biomarkers had predictive value for delayed graft function following kidney transplantation and confirmed to be upregulated by RT-qPCR in an expanded cohort.