Journal ArticleDOI
Pathways of cholesterol oxidation via non-enzymatic mechanisms.
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TLDR
In the absence of enzymatic catalysis in a pathway usually termed "autoxidation", which has been known for almost a century and observed under various experimental conditions, the susceptibility of cholesterol to non-enzymatic oxidation has raised considerable interest in the function of oxysterols as biological effectors and potential biomarkers for the non-invasive study of oxidative stress in vivo as discussed by the authors.About:
This article is published in Chemistry and Physics of Lipids.The article was published on 2011-09-01. It has received 203 citations till now. The article focuses on the topics: Reactive oxygen species & Autoxidation.read more
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Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence
TL;DR: The kinetic data and physiological molar ratio of vitamin E to substrates show that the peroxyl radicals are the only radicals that vitamin E can scavenge to break chain propagation efficiently and thatitamin E is unable to act as a potent scavenger of hydroxyl, alkoxyl, nitrogen dioxide, and thiyl radicals in vivo.
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The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer
TL;DR: This review addresses the oncopharmacological properties of curcumin at the molecular level, whereby the phenotypical/biological changes induced in cancer cells upon completion of theCurcumin-triggered signaling cascade(s) are addressed in the framework of the hallmarks of cancer.
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Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway.
Kurt Lucas,Michael Maes +1 more
TL;DR: The authors posit that activation of the TLR radical (ROS/RNS) cycle is a common pathway underpinning many “civilization” disorders and that targeting theTLR radical cycle may be an effective method to treat many inflammatory disorders.
Journal ArticleDOI
European contribution to the study of ROS : a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
Javier Egea,Isabel Fabregat,Yves Frapart,Pietro Ghezzi,Agnes Görlach,Thomas Kietzmann,Kateryna Kubaichuk,Ulla G. Knaus,Manuela G. López,Gloria Olaso-Gonzalez,Andreas Petry,Rainer Schulz,Jose Viña,Paul J Winyard,Kahina Abbas,Opeyemi S Ademowo,Catarina B. Afonso,Ioanna Andreadou,Haike Antelmann,Fernando Antunes,Mutay Aslan,Markus Bachschmid,Rui M. Barbosa,Vsevolod V. Belousov,Carsten Berndt,David A. Bernlohr,Esther Bertran,Alberto Bindoli,Serge P. Bottari,Paula M. Brito,Guia Carrara,Ana I. Casas,Afroditi Chatzi,Niki Chondrogianni,Marcus Conrad,Marcus S. Cooke,João G. Costa,Antonio Cuadrado,Pham My-Chan Dang,Barbara De Smet,Bilge Debelec-Butuner,Irundika H.K. Dias,Joe Dan Dunn,Amanda J. Edson,Mariam El Assar,Jamel El-Benna,Péter Ferdinandy,Ana Sofia Fernandes,Kari E. Fladmark,Ulrich Förstermann,Rashid Giniatullin,Zoltán Giricz,Anikó Görbe,Helen L Griffiths,Helen L Griffiths,Vaclav Hampl,Alina Hanf,Jan Herget,Pablo Hernansanz-Agustín,Melanie Hillion,Jingjing Huang,Serap Ilikay,Pidder Jansen-Dürr,Vincent Jaquet,Jaap A. Joles,Balaraman Kalyanaraman,Danylo Kaminskyy,Mahsa Karbaschi,Marina Kleanthous,Lars-Oliver Klotz,Bato Korac,Kemal Sami Korkmaz,Rafal Koziel,Damir Kračun,Karl-Heinz Krause,Vladimír Křen,Thomas Krieg,João Laranjinha,Antigone Lazou,Huige Li,Antonio Martínez-Ruiz,Reiko Matsui,Gethin J. McBean,Stuart P. Meredith,Joris Messens,Verónica Miguel,Yuliya Mikhed,Irina Milisav,Lidija Milkovic,Antonio Miranda-Vizuete,Miloš Mojović,María Monsalve,Pierre-Alexis Mouthuy,John F. Mulvey,Thomas Münzel,Vladimir R. Muzykantov,Isabel T.N. Nguyen,Matthias Oelze,Nuno G. Oliveira,Carlos M. Palmeira,Nikoletta Papaevgeniou,Aleksandra Pavićević,Brandán Pedre,Fabienne Peyrot,Marios Phylactides,Gratiela Gradisteanu Pircalabioru,Andrew R. Pitt,Henrik E. Poulsen,Ignacio Prieto,Maria Pia Rigobello,Natalia Robledinos-Antón,Leocadio Rodríguez-Mañas,Anabela P. Rolo,Francis Rousset,Tatjana Ruskovska,Nuno Saraiva,Shlomo Sasson,Katrin Schröder,Khrystyna Semen,Tamara Seredenina,Anastasia Shakirzyanova,Geoffrey L. Smith,Thierry Soldati,Bebiana C. Sousa,Corinne M. Spickett,Ana Stancic,Marie José Stasia,Holger Steinbrenner,Višnja Stepanić,Sebastian Steven,Kostas Tokatlidis,Erkan Tuncay,Belma Turan,Fulvio Ursini,Jan Vacek,Olga Vajnerova,Kateřina Valentová,Frank Van Breusegem,Lokman Varisli,Elizabeth A. Veal,A. Süha Yalçın,Olha Yelisyeyeva,Neven Žarković,Martina Zatloukalová,Jacek Zielonka,Rhian M. Touyz,Andreas Papapetropoulos,Tilman Grune,Santiago Lamas,Harald H.H.W. Schmidt,Fabio Di Lisa,Andreas Daiber +151 more
TL;DR: The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks and EU-ROS represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine.
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Oxysterols: From cholesterol metabolites to key mediators
TL;DR: The complex metabolism and molecular targets (including binding properties) of these bioactive lipids in human and mice are discussed and the genetic mouse models currently available to interrogate their effects in pathophysiological settings are discussed.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The role of lipid peroxidation and antioxidants in oxidative modification of LDL.
TL;DR: A comprehensive survey on the compositional properties of LDL relevant for its susceptibility to oxidation, on the mechanism and kinetics of LDL oxidation, and on the chemical and physico-chemical properties of HDL oxidized by exposure to copper ions is provided.
Journal ArticleDOI
A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.
TL;DR: It is found that a series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase mechanism involving free radical-catalyzed peroxidation of arachidonic acid, and that these prostanoids may participate as pathophysiological mediators in oxidant injury.
Journal ArticleDOI
An oxysterol signalling pathway mediated by the nuclear receptor LXRα
TL;DR: The results demonstrate the existence of a nuclear receptor signalling pathway for oxysterols and suggest that LXRα may be important as a sensor of cholesterol metabolites.
Journal ArticleDOI
Lipid hydroperoxide generation, turnover, and effector action in biological systems
TL;DR: An aspect of related interest that is under intensive investigation is lipid peroxidation/LOOH-mediated stress signaling, which may evoke a variety of cellular responses, ranging from induction of antioxidant enzymes to apoptotic death.
Related Papers (5)
Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis
Anne Vejux,Gérard Lizard +1 more
Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis.
Andrew J. Brown,Wendy Jessup +1 more