L
Luis Serrano
Researcher at Catalan Institution for Research and Advanced Studies
Publications - 22
Citations - 1141
Luis Serrano is an academic researcher from Catalan Institution for Research and Advanced Studies. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 15, co-authored 22 publications receiving 1033 citations. Previous affiliations of Luis Serrano include European Bioinformatics Institute & Pompeu Fabra University.
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Journal ArticleDOI
Transcriptome Complexity in a Genome-Reduced Bacterium
Marc Güell,Vera van Noort,Eva Yus,Wei-Hua Chen,Justine Leigh-Bell,Konstantinos Michalodimitrakis,Takuji Yamada,Manimozhiyan Arumugam,Tobias Doerks,Sebastian Kühner,Michaela Rode,Mikita Suyama,Sabine Schmidt,Anne-Claude Gavin,Peer Bork,Luis Serrano,Luis Serrano +16 more
TL;DR: Three papers provide a comprehensive and quantitative analysis of the proteome, the metabolic network, and the transcriptome of M. pneumoniae, a “simple” organism that makes extensive use of noncoding RNAs and has exon- and intron-like structure within transcriptional operons that allows complex gene regulation resembling that of eukaryotes.
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Bacterial antisense RNAs are mainly the product of transcriptional noise.
Verónica Lloréns-Rico,Verónica Lloréns-Rico,Jaime González Cano,Jaime González Cano,Tjerko Kamminga,Rosario Gil,Amparo Latorre,Wei-Hua Chen,Peer Bork,John I. Glass,Luis Serrano,Luis Serrano,Luis Serrano,Maria Lluch-Senar,Maria Lluch-Senar +14 more
TL;DR: It is shown, by comparative transcriptomics of 20 bacterial species and one chloroplast, that the number of asRNAs is exponentially dependent on the genomic AT content and that expression of asRNA at low levels exerts little impact in terms of energy consumption.
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Tumor suppressor properties of the splicing regulatory factor RBM10.
TL;DR: The previous and current results reveal that RBM10 is a tumor suppressor that represses Notch signaling and cell proliferation through the regulation of NUMB alternative splicing.
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Using a structural and logics systems approach to infer bHLH–DNA binding specificity determinants
Federico De Masi,Christian A. Grove,Anastasia Vedenko,Andreu Alibés,Stephen S. Gisselbrecht,Luis Serrano,Martha L. Bulyk,Albertha J.M. Walhout +7 more
TL;DR: This study provides insights into the mechanisms of DNA recognition by bHLH dimers as well as a blueprint for system-level studies of the DNA binding determinants of other TF families in different model organisms and humans.
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Assessing the limits of restraint-based 3D modeling of genomes and genomic domains
TL;DR: This work provides a systematic analysis of the limitations of a mean-field restrain-based method, which could be taken into consideration in further development of methods as well as their applications.