Luisa Imberti

TL;DR: Data indicate that decreased thymic function, B cell oligoclonality, and increased spontaneous apoptosis may be the mechanisms by which the immunodeficiency of ADA‐SCID patients persists in spite of treatment with PEG‐ADA.

TL;DR: The quantification of TRECs and KRECs, which can be reliably performed using singleplex or duplex real-time quantitative PCR, provides novel information in the management of T- and B-cell immunity-related diseases and can also been used as a surrogate marker of lymphocyte output in acquired immunodeficiencies.

TL;DR: The results show that “illegitimate” rearrangements occur with unexpectedly high incidence, specifically at the level of TCRBD to TCRBJ joining, and provide additional information for a more accurate estimation of the size of the TCRV repertoire and for understanding the well-established biased pattern of T CRBV expression in humans.

TL;DR: It is suggested that a combined defect in generation of B and T subpopulations may account for the abnormal immunophenotype characterizing this subgroup of CVID patients.

TL;DR: In this article, the authors evaluated the impact of genetic diagnosis, age, and treatment on antibody response to COVID-19 vaccine and related adverse events in a cohort of patients with inborn errors of immunity (IEIs).