Luisa Imberti

TL;DR: It is found that, at the individual-patient level, the response to IFN β therapy was extremely heterogeneous, including patients with stable or transitory, early or late loss of IFNβ bioactivity, and patients with samples lacking MxA mRNA induction in spite of absence of antibodies, and these data warrant the quantification of M xA mRNA as a primary tool for a routine monitoring ofIFNβ therapy.

TL;DR: The paradoxical increase of EM Treg in PB of patients with GVHD could be explained by their compartmentalization outside lymphoid tissues, which are of critical relevance for regulation of GVH reactions.

TL;DR: A common pattern of junctional diversity associated with different TCRBV segments is consistent with a strong on-going antigenic selection process, possibly related to the pathogenesis of Wiskott-Aldrich syndrome.

TL;DR: Increased levels of circulating neurofilament light chain (NfL), a biomarker of neuronal injury, have been observed in severe COVID‐19 patients and it is investigated whether NfL provides non‐redundant clinical value to previously identified predictors of CO VID‐19 mortality.

TL;DR: The findings suggest that the relative immunoincompetence observed in the newborn may result from a variety of mechanisms including a low percentage of helper-inducer (4B4+2H4-) T4+ lymphocytes possibly also associated to an increased number of suppressor-inducer T4+, as well as a high percentage of T 4+ cord blood cells that can coexpress both antigens.