L
Luke Peng
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 3
Citations - 1323
Luke Peng is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Mutation & Germline mutation. The author has an hindex of 3, co-authored 3 publications receiving 1168 citations.
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Journal ArticleDOI
Genome Sequencing Identifies a Basis for Everolimus Sensitivity
Gopa Iyer,Gopa Iyer,Aphrothiti J. Hanrahan,Matthew I. Milowsky,Matthew I. Milowsky,Hikmat Al-Ahmadie,Sasinya N. Scott,Manickam Janakiraman,Mono Pirun,Chris Sander,Nicholas D. Socci,Irina Ostrovnaya,Agnes Viale,Adriana Heguy,Luke Peng,Timothy A. Chan,Bernard H. Bochner,Dean F. Bajorin,Dean F. Bajorin,Michael F. Berger,Barry S. Taylor,David B. Solit,David B. Solit +22 more
TL;DR: The results demonstrate the feasibility of using whole-genome sequencing in the clinical setting to identify previously occult biomarkers of drug sensitivity that can aid in the identification of patients most likely to respond to targeted anticancer drugs.
Journal ArticleDOI
The Mutational Landscape of Adenoid Cystic Carcinoma
Allen S. Ho,Kasthuri Kannan,David M. Roy,Luc G. T. Morris,Ian Ganly,Nora Katabi,Deepa Ramaswami,Logan A. Walsh,Stephanie Eng,Jason T. Huse,Jianan Zhang,Igor Dolgalev,Kety Huberman,Adriana Heguy,Agnes Viale,Marija Drobnjak,Margaret Leversha,Christine E Rice,Bhuvanesh Singh,N. Gopalakrishna Iyer,C. René Leemans,Elisabeth Bloemena,Robert L. Ferris,Raja R. Seethala,Benjamin Gross,Yupu Liang,Rileen Sinha,Luke Peng,Benjamin J. Raphael,Sevin Turcan,Yongxing Gong,Nikolaus Schultz,Seungwon Kim,Simion I. Chiosea,Jatin P. Shah,Chris Sander,William Lee,Timothy A. Chan +37 more
TL;DR: The ACC mutational landscape is determined and the exome or whole-genome sequences of 60 ACC tumor-normal pairs are reported, finding mutations in genes encoding chromatin-state regulators, suggesting that there is aberrant epigenetic regulation in ACC oncogenesis.
Journal ArticleDOI
Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation
Luc G. T. Morris,Andrew Kaufman,Yongxing Gong,Deepa Ramaswami,Logan A. Walsh,Sevin Turcan,Stephanie Eng,Kasthuri Kannan,Yilong Zou,Luke Peng,Victoria E. Banuchi,P. Paty,Zhaoshi Zeng,Efsevia Vakiani,David B. Solit,Bhuvanesh Singh,Ian Ganly,Linda M. Liau,Timothy C. Cloughesy,Paul S. Mischel,Ingo K. Mellinghoff,Timothy A. Chan +21 more
TL;DR: Recurrent somatic mutations of the Drosophila melanogaster tumor suppressor–related gene FAT1 in glioblastoma, colorectal cancer, and head and neck cancer strongly point to FAT1 as a tumor suppressing gene driving loss of chromosome 4q35, a prevalent region of deletion in cancer.