Bernard H. Bochner

TL;DR: These data from a large group of patients support the aggressive surgical management of invasive bladder cancer and suggest excellent long-term survival can be achieved with a low incidence of pelvic recurrence.

TL;DR: Analysis of advanced cancer patients treated with immune-checkpoint inhibitors shows that tumor mutational burden, as assessed by targeted next-generation sequencing, predicts survival after immunotherapy across multiple cancer types.

TL;DR: A large-scale, prospective clinical sequencing initiative using a comprehensive assay, MSK-IMPACT, through which tumor and matched normal sequence data from a unique cohort of more than 10,000 patients with advanced cancer are compiled and identified clinically relevant somatic mutations, novel noncoding alterations, and mutational signatures that were shared by common and rare tumor types.

TL;DR: Ch Chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any other common cancer studied so far, indicating the future possibility of targeted therapy for chromatin abnormalities.

TL;DR: Surgical morbidity following radical cystectomy is significant and, when strict reporting guidelines are incorporated, higher than previously published.