Lutz Frölich

TL;DR: A SORL1 haplotype was found which was associated with CSF levels of amyloid-beta cleavage products, measured as altered levels of Abeta42, suggesting that SORl1 gene variants might influence AD pathology.

TL;DR: In MCI, specific aspects of SCD severity and quality are related to CSF biomarker signature indicative of prodromal AD together with either high CSF tau or CSF phosphorylated tau 181 levels.

TL;DR: Results are the first to indicate that reduced levels of brain-specific AC subtypes occur in DAT, and no significant difference in immunoreactivity of AC-V/VI subtypes distributed in various other tissues was observed.

TL;DR: Descriptive trends were found at the psychopathological and dynamic functional levels, which can be interpreted as evidence of effectiveness of Ginkgo biloba special extract EGb 761 in mild to moderate dementia and of local effects in the central nervous system.

TL;DR: Associations between rare TREM2 variants and specific FTD subtypes (FTD-S) are investigated to provide evidence that p.T96K is associated with FTD-D and that p-L211P may contribute to its pathogenic effect, and to suggest the p.R47H variants are associated with an FTD phenotype that is characterized by the presence of underlying AD pathology.